Inbred Strains
of Mice: SEC
Pale brown:
a,b,cch. Origin: Green
prior to 1946 from a cross between NB and BALB/c. Carries
se (short-ear)
gene causing short ears and skeletal abnormalities. Substrains as follows:
SEC/Rl
Inbr (Rl) 100 +. Colour ?:
a,b,cch,d,se
.Origin: E.L.Green 1948 to Rl at F20-F21. Maint. by J.
SEC/1Gn
Inbr (Le) 149. Gets multiple lung cysts, especially in
se/se.
SEC/1Re
Inbr (J) 138. From SEC/1Gn, but short-ear eliminated by E.S.Russell.
Characteristics
High shuttle-box avoidance (2/5) (
Messeri
et al., 1972., 1972). High plasma cholinesterase activity (7/22 in
females, 2/22 in males) (
Angel et al., 1967.,
1967). High hepatic delta-aminolaevulinic acid synthetase activity after
DDC treatment (3/15) (
Gross and Hutton, 1971).
Low sensitivity of females to X-irradiation (5/5) (
Ehling,
1964). Low lymphocyte phytohaemagglutinin response (31/43) (
Heiniger et al., 1975., 1975). Good reproductive performance
(1/5) (
Ehling, 1964).
Angel C.
R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability
of plasma cholinesterase activity in inbred mouse strains. Science
156, 529-530.
Ehling U. H. (1964)
Strain variation in reproductive capacity and radiation response of female
mice. Radiation Res. 23, 603-610.
Gross S.
and Hutton J. (1971) Induction of hepatic -aminolaevulinic acid synthetase
activity in strains of inbred mice. J. Biol. Chem. 246,
606-614.
Heiniger
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Messeri
P., Oliverio A., and Bovet D. (1972) Relations between avoidance and activity.
A diallel study in mice. Behav. Biol. 7, 733-742.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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