SHN

Inbr: F51 (Mei). Genet: c, A, b. Origin: Swiss albino mice from the City of Hope Medical Centre, California. Inbred as SWM/Ms by Natl. Inst. Genet. Misima. Selected for high early mammary tumour incidence with full-sib mating starting in 1964, and F20 in 1972.

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Characteristics

Have mammary tumour virus locus Mtv4 which is genetically transmitted rather than being passed through the milk (Imai et al 19830 1983). Tumour incidence 90-100% in breeders and virgins at 6.6 months. Litter size 7.6, weaning rate 89% (Nagasawa et al., 1976a, 1976a, b). See also SLN.

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Imai S., Tsubura Y., Hilgers J., and Michalides R. (1983) A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain. J. Natl. Cancer Inst. 71, 517-521.

Nagasawa H., Tokuzen R., and Nakahara W. (1976a) Growth of mammary tumors in a high and a low mammary tumor strains of mice established from the same basal stock of Swiss albino. Gann 67, 913-915.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK