Inbred Strains
of Mice: SSIN
Inbr (Utsp) 22+. Albino. Origin: 1970's, from outbred SENCAR (sensitive
to carcinogens) selected for high skin tumour number following challenge
for 10 generations with a topical application of dimethylbenz(a)anthracene
followed by repetitive application of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate
(TPA). Inbred in 1986.
Characteristics
Hardy animals with low spontaneous tumour incidence; useful in chemical
carcinogenesis studies because of extreme sensitivity to TPA (
Fischer et al 19870 1987). Low LD50 following injection
of butylated hydroxytoluene (BHT) (4/4) (
Kehrer
and DiGiovanni 1990)
Fischer
S. M., O'Connell J. F., Conti C. J., Tacker K. C., Fries J. W., Patrick
K. E., Adams L. A., and Slaga T. J. (1987) Characterization of an inbred
strain of the SENCAR mice that is highly sensitive to phorbol esters.
Carcinogenesis 8, 421-424.
Kehrer
J. P. and DiGiovanni J. (1990) Comparison of lung injury induced in 4
strains of mice by butylated hydroxytoluene. Toxicol. Lett. 52,
55-61.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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