Inbred Strains
of Mice: SWXL
Inbr. ?. Set of 7 recombinant inbred strains maintained at the Jackson
Laboratory.
SWXL-4 mice exhibit tonic-clonic and generalised seizures similar to the
commonest epilepsy in humans. Seizures are observed in routine handling
from about 80 days of age, and are due to a dominant gene Szf1
on chromosome 7 which accounts for about 32% of the variation in susceptibility
(Frankel et al, 1994).
Frankel
W. N., Taylor B. A., Noebels J. L., and Lutz C. M. (1994) Genetic epilepsy
model derived from common inbred mouse strains. Genetics 138,
481-489.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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