Inbred Strains
of Mice: WB
Inbr (J) 119. Black or black-eyed white:
a,W. Origin:
W (dominant
spotting) heterozygotes from S.J.Holman and S.G.Waelsch. Sib-mating started
in 1948.
Characteristics
WW homozygotes are anaemic, sterile, lack pigmentation in coat;
heterozygotes have normal blood picture and fertility, but white ventral
spotting; anaemics die at approximately 11 days. Many other anaemia-producing
mutant alleles are maintained congenic with this strain. Resistant to
lethal effects of ozone (19/22) (
Goldstein
et al., 1973., 1973). High lymphocyte phytohaemagglutinin response
(4/43) (
Heiniger et al., 1975., 1975).
Abnormal azygos vein which varied from a single unpaired vein on the
right side that connected to the right anterior vena cava through bilaterally
symmetrical and paired veins to the expected unpaired vein on the left
side found in most strains (
Biddle et al 1991).
Develop a high frequency of subcutaneous edema in day 15 fetuses when
mothers are treated with acetazolamide. A transient edema is also seen
in 56% of control mice. The condition appears to be due to more than one
gene (
Biddle 1990). Carry a single recessive
gene different from that found in BALB/cBy and C57BL/6J, causing age-related
hearing loss (
Willott et al, 1995).
Biddle
F. G., Jung J. D., and Eales B. A. (1991) Genetically determined variation
in the azygos vein in the mouse. Teratology 44, 675-683.
Biddle FG (1990) Genetically
determined transient edema found in the WB/ReJ mouse strain in a teratogenic
survey with acetazolamide. Teratology 42, 659-670.
Goldstein
B. D., Lai L. Y., Ross S. R., and Cuzzi-Spada R. (1973) Susceptibility
of inbred mouse strains to ozone. Arch. Environ. Health 27,
412-413.
Heiniger
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Willott
J. F., Erway L. C., Archer J. R., and Harrison D. E. (1995) Genetics of
age-related hearing loss in mice. II. Strain differences and effects of
caloric restriction on cochlear pathology and evoked response thresholds.
Hearing Research 88, 143-155.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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