Inbred Strains
of Rats: APR
Inbr. F50
Colour: Albino
Genet. c
Origin: Developed as strain "MF" by Holme and Piechuta (1979) by selective
breeding of Sprague-Dawley outbred rats. Individuals were injected sub-cutaneously
with egg albumin and B. pertussis vaccine i.p. then challenged with areosolised
egg albumin after 14-18 days. Individuals within litters with the most
severe symproms (longest duration of dyspnea) were selected and mated
brother x sister. Later re-named APR (Apnea Prone Rat).
Characteristics
Develop asthema-like symproms on challenge with aerosolised antigen.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
Analysis Tools