AS.

Inbr.F60+.

Colour: Albino.

Genet: c.

Origin: University of Otago from Wistar rats imported from England in 1930. May be subline of GH, with which it is histocompatible (Heslop and Phelan 1973).

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Characteristics

Hypertensive, though not to such an extent as GH (Heslop and Phelan 1973). Glomerular filtration rate and renal plasma flow studied by Hackbarth et al (1981), and haematology and its relation to diet studied by Hackbarth et al (1983). Susceptible to the development of experimetnal allergic encephalomyelitis (Hughes and Stedronska 1973). Susceptible to induction of autologous immune complex glomerulonephritis associated with the major histocompatibility complex (Stenglein et al 1975). Low antibody response to phytohaemagglutinin; not linked to MHC (Koch 1976). Long pentobarbitone sleeping time (2/10 males, 1/10 females, Vieregge et al 1987) Good reproductive performance.

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Hackbarth H., Baunack E., and Winn M. (1981) Strain differences in kidney function of inbred rats: 1. Glomerular filtration rate and renal plasma flow. Lab. Anim. 15, 125-128.

Hackbarth H., Burow K., and Schimansky G. (1983) Strain differences in inbred rats: Influence of strain and diet on haematological traits. Lab. Anim. 17, 7-12.

Heslop B. F. and Phelan E. L. (1973) The GH and AS hypertensive rat strains. Lab. Anim. 7, 41-46.

Hughes R. A. C. and Stedronska J. (1973) The susceptibility of rat strains to experimental allergic encephalomyelitis. Immunol. 24, 879-884.

Koch C. (1976) Genetic control of antibody responses to PHA in inbred rats. Scand.J. Immunol. 5, 1149-1153.

Stenglein B., Thoenes G. H., and Gunther E. (1975) Genetically controlled autologous immune complex glomerulonephritis in rats. J. Immunol. 115, 895-897.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK