AVN.

Inbr. F85 (Keil Univ.).

Colour: Albino.

Genet: c.

Origin: Unknown. Keil University from O Stark, Charles University, Prague.

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Characteristics

Will grow ferridextran-induced sarcoma FEDEX-AVN (Kren et al 1970b). Low secondary antibody response to the polypeptide (T,G)-Pro-Lys (19/20) (Gunther et al 1976). Resistant to the induction of experimental allergic encephalomyelitis, slightly susceptible to adjuvent-induced arthritis (Perlik and Zidek 1974). AVN to LEW lung grafts have been used to study acute rejection (Semik et al 1994)

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Gunther E., Mozes E., Rode E., and Sela M. (1976) Genetic control of immune responsiveness to poly ( Pro) poly ( Lys ) derived polypeptides by histocompatibility-linked immune response genes in the rat. J. Immunol. 117, 2047-2052.

Kren V., Krenova D., and Stark O. (1970b) Runt syndrome incidence and skin graft tolerance in various interstrain combinations of rats differing at a single or multiple histocompatibility loci. Folia Biol. 16, 305-313.

Perlik F. and Zideck Z. (1974) The susceptibility of several inbred strains of rats to adjuvant-induced arthritis and experimental allergic encephalomyelitis. Z. Immunitactsforsch. Exp. Klin. Immunol. 147, 191-193.

Semik M., Schnabel R., Bruske T., Lange V., Wottge H., Morgenrot K., and Toomes H. (1994) Ultrastructural studies of acute rejection following single-lung transplantation in the rat - histological and immunohistological findings. Thoracic and Cardiovascular Surgeon 42, 290-297.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK