AXC

Inbr.?.

Colour: Agouti with white belly and feet.

Genet. A hⁱ.

Origin: A substrain of ACI. Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Albert Segaloff of the Alton Ochsner Medical Foundation, New Orleans before 1956, to Southwestern Foundation for Biomedical Research in 1976.

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Characteristics

Median life-span 906 days in both sexes. There is a 25% incidence of moderate to severe nephropathy at 30-41 months. Pituitary adenomas in 65% of females and 10% of males, mammary adenocarcinoma in 26% of females, prostate adenocarcinomas in 23% of males older than 29 months (Gleiser and Shain 1986). Shain et al (1986) have used this strain to study age related decreases in ventral prostate content of moderately abundant, androgen responsive proteins.

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Gleiser C. A. and Shain S. A. (1986) The aging AXC/SSh rat: assessment of longevity and prevalence of neoplastic and nonneoplastic diseases in necropsied rats. J. Gerontol. 41, 590-598.

Shain S. A., Schultz J. J., and De L. C. (1986) Aging in the AXC/SSh rat: characterization of moderately abundant ventral prostate proteins showing age-dependent diminution and one protein exhibiting age-invariant content. Mech. Ageing Dev. 37, 147-162.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK