Origin: Strain developed by crossing BB/Wor rats, a lean model of type I diabetes mellitus with a Zucker fatty (fa) rat of unstated genetic background, followed by sib mating with forced heterozygosity for the fatty gene. Thus in each generation there is a ratio of 3:1 non-obese to obese animals.
Characterisitcs
This strain shares features of both parental strains. All rats are lymphopenic and about 50% develop diabetes by 120 days of age. Lean rats resemble the BB/Wor strain with an autoimmune destruction of the pancreatic B-cells, resulting in insulin-dependent, ketosis-prone diabetes. In contrast, in homozygous fatty rats B-cell destruction is incomplete, and the obese rats do not require insulin treatment for survival. Further details are given by Guberski et al (1990)
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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