Inbred Strains
of Rats: BDIX
Inbr. F?+50.
Colour: Agouti .
Genet: A, C, H, P.
Origin: see BDI.
Characteristics
Strain widely used in carcinogenesis and teratogenesis studies. Highly
susceptible to the transplacental induction of malignant tumours of the
central nervous system by ethyl nitrosourea (
Druckrey
et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced
by ethyl nitrosourea has been used as a model for chemotherapy (
Ivankovic and Zeller 1974). Transplantable colon tumour
PROb grows progressively and metastasizes, whereas REGb grows slowly and
is then rejected (
Blottiere et al 1992a,b).
DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as
an inhibitor (
Qin et al 1992). These models
have been used to study methods of treating peritoneal carcinoma including
shockwave cavitation (
Prat et al 1993) and
the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (
Gouyon et al 1995). A transplantable ovarian
carcinoma O-342 has been used in studies of potential chemotherapeutic
use of a methotrexate-albumin conjugate (
Steinmann
et al 1995). Transplantable Sp-5 colorectal adenocarcinoma has been
used in the study of the chemotherapeutic effects of 2'-deoxy-5-fluorouridine
for pulmonary metastises (
Ng et al 1995).
Has a defect in the expression of RT1.B, apparently due to absence of structural
or controling gene (Male et al 1987). The
activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual
patterns of expression in untreated animals (Herdegen
et al 1995).
Haematiology described by Lovell et al (1981);
high MCHC (7/7), neutrophils (7/7), low lymphocytes (1/7), high monocytes
(7/7), high eosinophils (7/7). Shows delayed development of the secondary
centre of ossification of the epiphyses of the long bones compared with
seven other strains (Stark et al, 1995).
Blottiere
H. M., Menoret A., Burg C., Douillard J. Y., and Lependu J. (1992a) Identification
and characterization of a rat protein (p-105) auto-antigenic in rats bearing
a progressive syngeneic colon-carcinoma. Int. J. Cancer 50,
315-320.
Druckrey
H., Landschutz C., and Ivankovic S. (1970) Transplacentare Erzeugnung
maligner Tumoren des Nervensystems. II. Athyl-nitrosoharnstoff an 10 genetisch
definierten Ratten-stammen. Z. Krebsforsch. 73, 371-386.
Gouyon
B. A., Reyldesmars F., Leromancer M., Pigeon C., Lewin M. J. M., and Lehy
T. (1995) In-vivo effect of somatostatin analog, lanreotide, and/or GRP
antagonist, BIM-26226, on the growth of colon-cancer peritoneal carcinomatosis
in the rat. International Journal of Oncology 7, 1167-1173.
Herdegen
T., Kovary K., Buhl A., Bravo R., Zimmermann M., and Gass P. (1995) Basal
expression of the inducible transcription factors C-jun, JunB, JunD, C-fos,
FosB, and Krox-24 in the adult-rat brain. J. Comp. Neurol. 354,
39-56.
Ivankovic
S. and Zeller W. J. (1974) Leukemia L5222 of the rat strain BDIX. Blut
28, 288-292.
Lovell
D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological
parameters among inbred strains. Lab. Anim. 15, 243-249.
Male D. K.,
Pryce G., and Butcher G. W. (1987) Serological evidence for a defect in
RT1.B (I-A) expression by the BDIX rat strain. J. Immunogenet.
14, 301-312.
Ng B., Lenert
J. T., Weksler B., Port J. L., Ellis J. L., and Burt M. E. (1995) Isolated
lung perfusion with FUDR is an effective treatment for colorectal adenocarcinoma
lung metastases in rats. Annals of Thoracic Surgery 59,
205-208.
Prat F., Chapelon
J. Y., Elfadil F. A., Theillere Y., Ponchon T., and Cathignol D. (1993)
Invivo effects of cavitation alone or in combination with chemotherapy
in a peritoneal carcinomatosis in the rat. Brit. J. Cancer 68,
13-17.
Qin Y. F., Vancauteren
M., Osteaux M., Schally A. V., and Willems G. (1992) Inhibitory effect
of somatostatin analog RC-160 on the growth of hepatic metastases of colon
cancer in rats - a study with magnetic-resonance-imaging. Cancer Res.
52, 6025-6030.
Stark C.,
Kahrmann B., and Walzel E. (1995) Epi-and metaphyseal morphology in the
long bones of BDIX/Han rats. Lab. Anim. 30, 35-41.
Steinmann
A., Friedrich E., and Rath U. (1995) A novel methotrexate-albumin (MTX-RSA)-conjugate
causes significant growth delay of O-342 ovarian-carcinoma in-vivo. Oncology
Reports 2, 107-109.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK