BIL/1 and BIL/2

Inbr. F30 (Pit, 1992).

Colour: Dilute cinnamon-hooded.

Genet: ?.

Origin: University of Pittsburgh from a mutation in a colony of unknown background held by the NIH.

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Characteristics

BIL/1 carries growth and reproduction mutation (grc) which is also associated with incresed sensitivity to chemical carcinogens and is associated with the RT1 locus, and maintained by forced heterozygosity (RT1^l,n). It is due to a 70kb deletion within the RT1 complex, and defects are probably due to loss of genes in this segment of chromosome. BIL/2 is a normal control (Vardimon et al, 1992).

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Vardimon D., Locker J., Kunz H. W., and Gill T. J. (1992) Physical mapping of the MHC and Grc by pulse field electrophoresis. Immunogenet. 35, 166-175.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK