CAR

Inbr. F108 (N, 1988).

Colour: Albino.

Genet: c.

Origin: Hunt 1937, developed for resistance to dental caries (Hunt et al 1955).

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Characteristics

Poor reproductive performance (19/12) and low litter size (9/12). Dislikes handling (Hansen et al 1973). Takes longer to develop dental caries, and incidence of Streptococcus salivarius and lactobacilli lower than in CAS (Hunt et al 1955).Susceptible to the induction of experimental allergic encephalomyelitis (Gasser et al 1975).

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Gasser D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J. Immunol. 115, 431-433.

Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalogue of NIH Rodents. DREW Publ. No. 74-606. Department of Health, Education, and Welfare, Washington, D.C.: U.S.

Hunt H. R., Hoppert C. A., and Rosen S. (1955) Genetic factors in experimental rat caries. Pp. 66-81 in Advances in Experimental Caries Research, R. F. Washington, D.C.: American Association for the Advancement of Science, Sognnaes, ed.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK