DSS/1 to DSS/3.

Inbr. F21, F20 and F23, respectively.

Colour: Albino

Genet. c.

Origin: Three inbred strains developed from outbred Sprague-Dawley stock selected for sensitivity to sodium chloride-induced hypertension (Dahl et el 1962a, b). Inbred by Iwai and then Hansen (N).

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Characteristics

Sensitive to salt-induced hypertension. Should not be confused with SS and SR developed by Dr. John Rapp (see also SS/Jr). A congenic strain resulting from the backcrossing of the "corpulent" (cp) or (more correctly) fatty-Koletsky (fa^K ) gene onto the DSS genetic background has been described and designated DSS/N-cp by Michaelis et al (1995).

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Michaelis O. E., Velasquez M. T., Abraham A. A., Servetnick D. A., Scholfield D. J., and Hansen C. T. (1995) Development and characteristics of a new strain of obese hyperinsulinemic and hyperlipidemic Dahl salt-sensitive rat - the Dahl salt-sensitive/NIH-corpulent rat. AJH 8, 467-473.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK