Inbred Strains
of Rats: HXB
Inbr.F17-21 (Ipcv 1988).
Origin: Set of 17 recombinant inbred strains developed by Pravenec, Klir
and Kren from a cross between SHR/OlaIpcv and BN.ix/CubIpcv, and described
by Pravenec et al (1988). Strains have
now been typed at 500 loci and scanned for quantitative trait loci associated
with blood pressure and heart weight (Pravenec
et al, 1995).
Pravenec
M., Klir P., and Kren V. (1988) The assignment of ES-6 locus to the LGVII
of the rat and the production of HXB set of recombinant inbred strains.
Rat News Lett. 20, 12-13.
Pravenec
M., Gauguier D., Schott J. J., Buard J., Kren V., Bila V., Szpirer C.,
Szpirer J., Wang J. M., Huang H. M., Stlezin E., Spence M. A., Flodman
P., Printz M., Lathrop G. M., Vergnaud G., and Kurtz T. W. (1995) Mapping
of quantitative trait loci for blood-pressure and cardiac mass in the
rat by genome scanning of recombinant inbred strains. J. Clin. Invest.
96, 1973-1978.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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