Inbred Strains
of Rats: LA
Inbr. F89 (NIH 1989).
Colour: Black:
Genet. a,H.
Origin: from a cross between ALB/N and a hooded stock of unknown origin
(Hansen et al 1982).
Characteristics
Good reproductive performance. LA is mainly used as control for congenic
strain LA/N-
cp (ie carrying the 'corpulent' gene, an allele of
'fatty') in studies of obesity (
see Tulp 1990
for a review). High 10-week body weight in males (21/23) (
Tanase et al 1982). Low relative heart weight in 10-week
old males (1/23) (
Tanase et al 1982).
Diabetes in LA/N-cp occurs in 80% of male obese and 17% of female obese
rats from six months of age (
Tulp and Weng,
1992). Glucose turnover in lean and obese LA rats has been described
by Berdanier et al, (
1993). Obese rats
have twice the capacity to synthesise body fat and cholesterol, but have
a reduced capacity to degrade cholesterol, leading to an accumulation
of cholesterol and fat (
Ghosh et al, 1995).
Berdanier
C. D., Pan J. S., Hartle D. K., and Michaelis O. E. (1993) Glucose-turnover
in lean and obese rats of the SHE/N-cp and LA/N-cp strains. Comparative
Biochemistry and Physiology B-Biochemistry & Molecular Biology 106,
87-94.
Ghosh P.,
Somanchi M., and Lakshman M. R. (1995) Regulatory enzymes of lipid-metabolism
in LA/N-cp rats. Journal of Nutritional Biochemistry 6,
348-352.
Hansen
C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents:
(1980). Catalogue. NIH Publ. No. 83-606. Department of Health and
Human Services, Washington, D.C.: U.S.
Tanase
H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred
strains of rats. Part 1. Genetic determination of the development of cardiovascular
enlargement in rats. Hypertension 4, 864-872.
Tulp O. L.
and Weng M. (1992) Effect of genetic dilution on development of diabetes,
impaired glucose-tolerance and invitro glucose-oxidation in LA/n-cp X
SHR/n-cp F1-hybrid rats. Comparative Biochemistry and Physiology A-Comparative
Physiology 101, 403-408.
Tulp O. L. (1990) Characteristics
of thermogenesis, obesity and longevity in the LA/N-cp rat. ILAR News
32, 32-38.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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