LEJ

Inbr. F68.

Colour: Black hooded.

Genet. a, h.

Origin: Hok 1956 from Pacific Farms, USA as an outbred stock (Sasaki, personal communication).

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Characteristics

Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf WKAH, W/M, LEW and BUF, but in contrast with TO) (Sasamoto et al, 1994). Moderately sensitive to the development of experimental glomerulonephritis following injection of nephritogenic antigen from bovine renal basement membrane (3/10) (Naito et al, 1991)

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Naito I., Kagawa M., Sado Y., and Okigaki T. (1991) Strain specific responses of inbred rats on the severity of experimental autoimmune glomerulonephritis - presence of a broad- spectrum of the susceptibility. International Journal of Immunopathology and Pharmacology 4, 145-154.

Sasamoto Y., Kotake S., Yoshikawa K., Wiggert B., Gery I., and Matsuda H. (1994) Interphotoreceptor retinoid-binding protein-derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Current Eye Research 13, 845-849.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK