Inbred Strains
of Rats: LER
Inbr. F30 (NIH 1989).
Colour: Albino.
Genet. c.
Origin: Originally designated Le-R and thought to be a mutation within
LEW conferring resistance of experimental allergic encephalomyelitis (EAE)
(Waxman et al, 1981, Driscoll et al 1985, Gasser
et al, 1983). However, it now appears to have been an accidental genetic
contamination by BUF/N rats (Goldmuntz
et al, 1993),. See LEW, Immunology.
Characteristics
Resistant to the induction of EAE, though susceptible to adoptively transferred
EAE when they are injected with encephalitogenic T cells from EAE-susceptible
LEW rats (
Blankenhorn et al, 1995).
Blankenhorn
E. P., Stranford S. A., Martin A. M., and Hickey W. F. (1995) Cloning
of myelin basic protein-reactive T-cells from the experimental allergic
encephalomyelitis-resistant rat strain, LER. J. Neuroimmunol.
59, 173-183.
Driscoll
B. F., Kies M. W., and Alvord J. E. C. (1985) The nature of the defect
in experimental allergic encaphalomyelitis (EAE)-resistant Lewis (Le-R)
rats. J. Immunol. 134, 1567-1570.
Gasser
D. L., Hickey W. F., and Gonatas N. K. (1983) The genes for nonsusceptibility
to EAE in the Le-R and BH strains are not linked to RT1. Immunogenet.
17, 441-444.
Goldmuntz
E. A., Wilder R. L., Goldfarb Y., Cash J. M., Zha H. B., Crofford L. J.,
Mathern P., Hansen C. T., and Remmers E. F. (1993) The origin of the autoimmune
disease-resistant LER rat - an outcross between the Buffalo and autoimmune
disease-prone Lewis inbred rat strains. J. Neuroimmunol. 44,
215-219.
Waxman
F. J., Perryman L. E., Hinrichs D. J., and Coe J. E. (1981) Genetic resistance
to the induction of experimental allergic encephalomyelitis in Lewis rats.
I. Genetic analysis of an apparent mutant strain with phenotypic resistance
to experimental allergic encephalomyelitis. J. Exp. Med. 153,
61-74.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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