LOU/C

Inbr. F35.

Colour: Albino.

Genet. c.

Origin: Bazin and Beckers from rats of presumed Wistar origin kept at the Universite Catholique de Louvain. LOU/C was selected among 28 parallel sublines for its high incidence of plasmacytomas, and LOU/M for its low incidence. The two are histocomaptible (Bazin 1977, Bazin and Beckers 1978).

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Characteristics

Develop spontaneous plasmacytomas after about 8 months of age, with an incidence of about 30% in males and 16% in females. These develop rapidly, and may be detected by palpation. They usually develop in the ileocoecal lymph nodes, and about 60% of them synthesise monoclonal immunoglobulins (Bence-Jones proteins) of IgG1 (35%), IgE (36%) or IgA classes. Surgical removal of ileocaecal lymph nodes decreases plasmacytoma incidence to less than 2% (Moriame et al 1977). Ultrastructure of the tumours described by Burtonboy et al (1978). Tumours are transplantable in solid or ascites form, and retain their secretory properties through successive passages (Bazin et al 1972, Bazin et al 1973, Bazin 1974, Bazin et al 1974a,b, Beckers and Bazin 1978). More than 800 transplantable immunocytomas are now available.

LOU/M

Inbr. F?+36.

Colour: Albino.

Genet. c.

Origin: see LOU/C. Histocompatible with LOU/C and maintained by selection of LOU/M males on the basis of acceptance of skin grafts from LOU/C rats (Bazin 1977, Beckers and Bazin 1978).

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Characteristics

Good antibody response to ovalbumin with Bordetella pertussis organsisms as adjuvent (Bazin and Platteau 1976). Susceptible to the development of cerebral malaria when inoculated with Plasmodium berghei ANKA (Neill 1991).

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Bazin H., Deckers C., Beckers A., and Heremans J. F. (1972) Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU/Wsl strain rat immunocytomas and their monoclonal proteins. Int. J. Cancer 10, 568-580.

Bazin H., Beckers A., Deckers C., and Moriame M. (1973) Transplantable immunoglobulin-secreting tumors in rats. V. Monoclonal immunoglobulins secreted by 250 ileocecal immunocytomas in LOU/Wsl rats. J. Natl. Cancer Inst. 51, 1359-1361.

Bazin H., Beckers A., and Querinjean P. (1974a) Three classes and four (sub)classes of rat immunoglobulins: IgM. IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur. J. Immunol. 4, 44-48.

Bazin H. and Platteau B. (1976) Production of circulating reaginic (IgE) antibodies by oral administration of ovalbumin to rats. Immunol. 30, 679-683.

Bazin H. (1974) Tumeurs secretant des immunoglobulines chez le rat LOU/Wsl. Etude portant sur 200 immunocytomes. Ann. Immunol. (Paris) 125C, 277-279.

Bazin H. (1977) Inbred strains. Rat News Lett. 1, 27.

Beckers A. and Bazin H. (1978) Incidence of spontaneous ileocecal immunocytomas in hybrids of LOU/C rats and rat strains with low spontaneous tumor incidence: Brief communication. J. Natl. Cancer Inst. 60, 1505-1508.

Burtonboy G., Beckers A., Rodhain J., Bazin H., and Lamy M. E. (1978) Rat ileocecal immunocytoma. An ultrastructural study with special attention to the presence of viral particles. J. Natl. Cancer Inst. 61, 477-484.

Moriame M., Beckers A., and Bazin H. (1977) Decrease in the incidence of malignant ileo-caecal immunocytome in LOU/C rats after surgical removal of the ileo-caecal lymph nodes. Cancer Lett. 3, 139-143.

Neill L. A. (1991) LOU/M rats dvelop cerebral malaria when inoculated with Plasmodium beraghei ANKA. Rat News Lett. 24, 7-9.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK