Inbred Strains
of Rats: MAXX
Inbr. F20+?.
Colour: Black hooded.
Genet. a, h.
Origin: from a cross of BNxLEW with subsequent inbreeding.
Characteristics
Like strain BN, but in contrast to 17 other strains MAXX is susceptible
to the development of mercury-induced autoimmunity to renal basement membranes
with the development of membraneous glomerulonephritis (
Henry et al 1988). Used to study alloantigen Eag-1 (
Blankert et al 1987).
MF
See APR
Blankert
J. J., Muizert Y., van Es L. A., and Paul L. C. (1987) Cellular requirements
for the induction of a humoral immune response to the endothelial alloantigen
Eag-1. Transplant. Proc. 19, 3151-3152.
Henry G.
A., Jarnot B. M., Steinhoff M. M., and Bigazzi P. E. (1988) Mercury-induced
renal autoimmunity in the MAXX rat. Clin. Immunol. Immunopathol.
49, 187-203.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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