MW (Reserved symbol)

Colour: Albino.

Genet. c.

Origin: Munich Wistar stock selected for superficial glomeruli and inbred by Harlan-Sprague-Dawley, now at F17 (1990). See also MWF and WMS.

Charcateristics

Susceptible to the development of experimental autoimmune myasthenia gravis (9/9) (Biesecker and Koffler 1988). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also M520) (Omiecinski et al, 1992). Provides a useful model for the study of renal microcirculation, which is extremely sensitive to endothelin-1 (Saito et al, 1994)

Omiecinski C. J., Ramsden R., Rampersaud A., and Walz F. G. (1992) Null phenotype for cytochrome-P450-2b2 in the rat results from a deletion of its structural gene. Molec. Pharmacol. 42, 249-256.

Saito M., Homma S., Yamatsu I., Sato M., and Ohshima N. (1994) Visualization of renal microcirculation in isolated Munich-Wistar rat kidneys - effects of endothelin-1 on renal hemodynamic activity. Jpn. J. Pharmacol. 66, 221-229.