NBL

Inbr. F?+30 (Cr 1989).

Colour: Black hooded.

Genet. a, h.

Origin: Bogden in the mid-1970s from Noble (Nb) strain rats (brother x sister mated but not descended from a single pair, and therefore not necessarily isogenic). To Fredrich Cancer Research facility in 1978. Note that the strain name NBL was selected in 1989. In the literature these rats are called Noble or Nb rats, usually without identifying whether the animals came from the non-isogenic colony of Dr. Noble or from the isogenic colony at the National Cancer Institute (Greenhouse et al 1990).

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Characteristics

Good reproductive performance. Hyperplasia and dysplasia of the dorsolateral prostate caused by implantation of testosterone and estradiol-17ß-filled silastic capsules. Prolonged implantation leads to prostatic carcinoma (Leav et al 1988, 1989).

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Greenhouse D. D., Festing M. F. W., Hasan S., and Cohen A. L. (1990) Catalogue of inbred strains of rats, in Genetic monitoring of inbred strains of rats (Hedrich H. J., ed), pp. 410-480. Gustav Fischer, Stuttgart, New York. (Gustav Fischer; Stuttgart, New York; N)

Leav I., Ho S.-M., Ofner P., Merk F. B., Kwan Pw-L., and Damassa D. (1988) Biochemical alterations in the sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats. J. Natl. Cancer Inst. 80, 1045-1053.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK