NBR

Inbr. F29.

Colour: Black.

Genet. a.

Origin: Poiley 1966 from heterogeneous stock.

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Characteristics

Good reproductin, active, small. S5B is closely related (see S5B). Uniquely, males do not synthesis a_2u-globulin, and as an apparent consequence do not develop renal hyaline droplets and nephropathy associated with exposure to certain chemicals (Ridder et al 1990, Chatterjee et al 1989). Morphene increases nose-poking behaviour, and phenobarbital decreases it, in contrast with F344 (Witkin and Goldberg, 1992). Intermediate rate of morphine self-administration (LEW high, F344 low), but rapid extinction (Ambrosio et al, 1995).

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Ridder G. M., von B. E. C., Alden C. L., and Parker R. D. (1990) Increased hyalin droplet formation in male rats exposed to decalin is dependent on the presence of 2u-globulin. Fundam. Appl. Toxicol. 15, 732-743.

Witkin J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, pentobarbital and morphine on schedule-controlled responding in 2 inbred rat strains that differ in locomotor stimulatory effects of cocaine. Behavioural Pharmacology 3, 455-463.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK