NEDH

Inbr. F?+8 (Sim 1990).

Colour: Albino.

Genet. a, B, c, h, P, R.

Origin: Slonaker (Univ. of Chicago ca 1928) rats inbred by S Warren at the New England Deaconess Hospital, to Simonsen Laboratories in 1985 via B Hoffman, Palo Alto, California. To Mollegaard in 1987 (Greenhouse et al 1990).

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Characteristics

Good reproductive performance. Pheochromocytomas develop spontaneously in 59% of 700-900 day-old males and in 81% of males 900 days or older. Almost always arise in the adrenal medulla, and about 50% occur bilaterally (Manger et al 1985). NEDH carrying transplanted pheochromocytomas have plasma norepinephrine concentrations 40-fold higher than age-matched controls, and provide a model of cardiomyopathy and other effects of prolonged exposure to catecholamines (Prokocimer et al 1987, 1988, Rosenbaum et al 1986, 1987, 1988)

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Greenhouse D. D., Festing M. F. W., Hasan S., and Cohen A. L. (1990) Catalogue of inbred strains of rats, in Genetic monitoring of inbred strains of rats (Hedrich H. J., ed), pp. 410-480. Gustav Fischer, Stuttgart, New York. (Gustav Fischer; Stuttgart, New York; N)

Manger W. M., Gifford J. R. W., and Hoffman B. B. (1985) Pheochromocytoma: a clinical and experimental overview. Curr. Probl. Cancer 9, 1-89.

Prokocimer P. G., Maze M., and Hoffman B. B. (1987) Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. J. Pharmacol. Exp. Therapeut. 241, 870-874.

Rosenbaum J. S., Zera P., Umans V. A., Ginsburg R., and Hoffman B. B. (1986) Desensitization of aortic smooth muscle contraction in rats harboring pheochromocytoma. J. Pharmacol. Exp. Therapeut. 238, 396-400.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK