NSD

Inbr. F68.

Colour: Albino,

Genet.c.

Origin: NIH, Bethesda, 1964 from a non-inbred (Sprague-Dawley) stock.

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Characteristics

Used for studies of mammary carcinomas. High systolic blood pressure (4/17), intermediate breeding performance (6/12) and litter size (5/12) (Hansen et al 1973). Low relative heart weight in 10-week old males (5/23) (Tanase et al 1982). Slow acetylator due to polymorphism of N-acetyltransferase (like WKY but contrast PETH) (Juberg et al, 1991)

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Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalogue of NIH Rodents. DREW Publ. No. 74-606. Department of Health, Education, and Welfare, Washington, D.C.: U.S.

Juberg D. R., Bond J. T., and Weber W. W. (1991) N-acetylation of aromatic-amines - genetic-polymorphism in inbred rat strains. Pharmacogenetics 1, 50-57.

Tanase H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 4, 864-872.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK