NZR

Inbr. F32+.

Colour: Albino.

Genet. c.

Origin: Subline of AS2 separated at F32.

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Characteristics

Tumours (atriocaval epithelial mesotheliomas) of right atrium or inferior vena cava occur in approximately 12-20% of animals of both sexes over 1 year. These tumours are slow growing, but apparently malignant, and closely resemble similar tumours found in humans (Goodall et al 1975). In a later study, most common neoplasms of animal over one year of age: atrioclaval mesotheliomas 12%, lung adenomas 10% (males), pituitary adenomas 23%, mammary tumours 7%, liver tumours 3%, cervical tumours 3% (in females) (Goodall and Doesburg 1981).

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Goodall C. M., Christie G. S., and Hurley J. V. (1975) Primary epithelial tumour in the right atrium of the heart and inferior vena cava in NZR/Gd inbred rats; pathology of 18 cases. J. Pathol. 116, 239-251.

Goodall C. M. and Doesburg R. M. N. (1981) Age-specific incidence of neoplasms in untreated N2R/Gd rats: An inbred strain with cardiovascular tumours and liver glycogen storage disease. J. Pathol. 135, 147-157.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK