OXYR

Inbr>75.

Colour: Albino.

Genet. c.

Origin: Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Salganik and Solovyova from Wistar stock, in contrast to OXYS rat strain by selection for resistance to cataractogenic effect of galactose rich diet and brother-sister mating of highly resistant rats. In 1992, due to new findings, the symbol R was assigned to this strain. However, since this R symbol has previously been used to designate the Dahl Salt resistant strain, the symbol now assigned to this strain is OXYR.To Division of Laboratory Animal Medicine, the University of North Carolina at Chapel Hill, 1994 at F72.

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Characteristics

Resistant to cataractogenic effect of galactose-rich diet (Solovyova et al 1975). Good breeding performance. Monosaccharide transport into the cells and the levels of hydroxyl radical generation and lipid peroxydation are close to that in the healthy Wistar rats.

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Solovyova N. A., Morozkova T. S., and Salganik R. I. (1975) Development of the inherited galactosemia symptoms in rats. Genetika 5, 63-72.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK