PETH

Inbr. F71.

Colour: Pink-eyed tan-hooded.

Genet. a, h, p.

Origin: Bourne 1938, to Sidman at F9N1, to NIH in 1966 at F9N1F18. Should probably be regarded as a subline of RCS.

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Characteristics

Carries gene for retinal dystrophy (rdy), causing cataracts by about 3 months of age. Secondary effects include unusual lens reflection and persistant hyaloid artery (Hansen et al 1973) Low systolic blood pressure (13/17) (Hansen et al 1973). Low blood pressure (19/23), reaching 124_1.7 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Low 10-week body weight in males (3/23) (Tanase et al 1982). Good reproductive performance.

Rapid acetylator due to polymorphism of N-acetyltransferase (contrast WKY and NSD) (Juberg et al, 1991)

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Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalogue of NIH Rodents. DREW Publ. No. 74-606. Department of Health, Education, and Welfare, Washington, D.C.: U.S.

Juberg D. R., Bond J. T., and Weber W. W. (1991) N-acetylation of aromatic-amines - genetic-polymorphism in inbred rat strains. Pharmacogenetics 1, 50-57.

Tanase H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 4, 864-872.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK