S5B

Inbr. N5F38.

Colour: Albino,

Genet. a, c.

Origin: Poiley 1955 from a cross of outbred NBR rats x Sprague-Dawley, with five generations of backcrossing of the albino gene followed by sib mating.

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Characteristics

High tolerance to toxic compounds (?). Good learning. Resistant to dietary induction of obesity (1/7) (Schemmel et al 1970, Buchanan et al, 1992). Enterostatin had no effect on the uptake of high, versus low fat diets after an overnight fast (contrast strain OM) (Okada et al, 1992). Moderate exercise in young females failed to reduce body fat (Schemmel et al, 1992). However, voluntary running in rats fed high fat or high carbohydrate diets resulted in significant weight loss, with a reduction in the weight of fat depots (Chang et al, 1995)

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Buchanan T. A., Fisler J. S., Underberger S., Sipos G. F., and Bray G. A. (1992) Whole-body insulin sensitivity in Osborne-Mendel and S5B/Pl rats eating a low-fat or high-fat diet. Am. J. Physiol. 263, R785-R789.

Chang L. T., Kras K., Suzuki K., Strasburg G., Rodgers C. D., and Schemmel R. A. (1995) Voluntary running in male S5B/Pl rats fed high-fat or high- carbohydrate diets. Physiol. Behav. 57, 501-508.

Okada S., York D. A., Bray G. A., Mei J., and Erlansonalbertsson C. (1992) Differential inhibition of fat intake in 2 strains of rat by the peptide enterostatin. Am. J. Physiol. 262, R1111-R1116.

Schemmel R., Mickelsen O., and Gill J. L. (1970) Dietary obesity in rats: Body weight and body fat accretion in seven strains of rats. J. Nutrit. 100, 1041-1048.

Schemmel R. A., Hannum S. H., Rosekrans J. A., and Heusner W. W. (1992) Moderate exercise in young female S5B/Pl rats does not reduce body- fat. Physiol. Behav. 52, 577-581.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK