UChA

Inbr.F63.

Colour: Albino,

Genet. c.

Origin: Wistar rats selected for low voluntary 10% ethanol consumption, with brother x sister mating.

---

Characteristics

Mean daily voluntary intake of 10% ethanol solution 0.64 ml in males and 0.61 ml in females (cf UChB). Voluntary consumption of 10% ethanol declines over a period of time. UChA and UChB do not differ in length of alcohol narcosis induced by 60 mmol/kg ethanol given intraperitoneally (Mardones and Segovia-Riquelme 1983). Effects of diet and disulfiram have been studied by Quintanilla et al (1993). Strains UCHA and UCHB differ in acetaldehyde metabolism (Tampier et al, 1994). Fro other studies on UCHA and UCHB see Tampier et al (1995).

---

Mardones J. and Segovia-Riquelme N. (1983) Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav. Toxicol. Teratol. 5, 171-178.

Quintanilla M. E., Sepulveda S., and Tampier L. (1993) Effect of diet and disulfiram on acetaldehyde blood-levels after ethanol in UCHA and UCHB rats. Alcohol 10, 381-385.

Tampier L., Quintanilla M. E., and Mardones J. (1994) Acetaldehyde metabolism - differences between UCHA and UCHB rats. Alcohol and Alcoholism 29, 751-755.

Tampier L., Quintanilla M. E., and Mardones J. (1995) Effects of aminotriazole on ethanol, water, and food-intake and on brain catalase in UCHA and UCHB rats. Alcohol 12, 341-344.

---

INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK