WDF

Inbr. N11F11 (1986).

Colour: Albino.

Genet. c.

Origin: Ikeda et al (1981) by backcrossing the fatty gene (fa) to F8 and later generations of outbred Wistar Kyoto rats being inbred by brother x sister mating. The aim was to develop a model of non-insulin-dependent diabetes mellitus.

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Characteristics

The animals exhibit hyperglycemia, hyperinsulinemia, peripheral and hepatic insulin resistance linked to abnormalities in enzyme levels and activities, diet and sex-dependent diabetes and possible diabetes-linked peripheral neuropathy (Kava et al 1990).

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Ikeda H., Shino A., and Matsuo T. (1981) A new genetically obese-hyperglycemic rat (Wistar fatty). Diabetes 30, 1045-1050.

Kava R., Peterson R. G., West D. B., and Greenwood M. R. C. (1990) Wistar diabetic fatty rat. ILAR News 32, 9-12.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK