WKHT (reserved symbol)

Inbr. F17 (1991).

Colour: Albino.

Genet. c.

Origin: From a cross between SHR and WKY, with selection for high blood pressureand low spontaneous activity (Hendley et al 1988, Knardahl and Hendley 1990, Hendley and Fan, 1992).

---

Characteristics

Have been used as a model for studying the effects of drugs on aortic aneurysms. Propranolol significantly reduces the size of abdominal aortic aneurysms independently of the dose and by a mechanism which may be unrelated to blood pressure (Slaiby et al, 1994)

---

Hendley E. D., Cierpial M. A., and MacCarthy R. (1988) Sympathetic-adrenal medullary response to stress in hyperactive and hypertensive rats. Physiol. Behav. 44, 47-51.

Hendley E. D. and Fan X. M. (1992) Regional differences in brain norepinephrine and dopamine uptake kinetics in inbred rat strains with hypertension and or hyperactivity. Brain Res. 586, 44-52.

Knardahl S. and Hendley E. D. (1990) Association between cardiovascular reactivity to stress and hypertension or behavior. Am. J. Physiol. (Heart Circ. Physiol.) 28, H248-H257.

Slaiby J. M., Ricci M. A., Gadowski G. R., Hendley E. D., and Pilcher D. B. (1994) Expansion of aortic-aneurysms is reduced by propranolol in a hypertensive rat model. Journal of Vascular Surgery 20, 178-183.

---

INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK