Smim27 Gene Detail

Summary

• Symbol
  Smim27
• Name
  small integral membrane protein 27
• Synonyms
  2010003O02Rik, Toporsos

• Feature Type
  protein coding gene
• IDs
  MGI:1913684
  NCBI Gene: 100504309
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr4:40269579-40270228 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 20.24 cM, cytoband A5
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  68 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913684	protein coding gene	Chr4:40269579-40270940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0003885	antisense lncRNA gene	Chr4:38122606-38126591 (+)
A/J	MGP_AJ_G0003865	antisense lncRNA gene	Chr4:36712658-36714004 (+)
AKR/J	MGP_AKRJ_G0003842	antisense lncRNA gene	Chr4:37608152-37609544 (+)
BALB/cJ	MGP_BALBcJ_G0003852	antisense lncRNA gene	Chr4:37015492-37017046 (+)
C3H/HeJ	MGP_C3HHeJ_G0003797	antisense lncRNA gene	Chr4:38178253-38179610 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0003996	antisense lncRNA gene	Chr4:39566038-39567415 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003493	antisense lncRNA gene	Chr4:34411902-34413419 (+)
CAST/EiJ	MGP_CASTEiJ_G0003763	antisense lncRNA gene	Chr4:37848218-37849606 (+)
CBA/J	MGP_CBAJ_G0003791	antisense lncRNA gene	Chr4:40897822-40899181 (+)
DBA/2J	MGP_DBA2J_G0003806	antisense lncRNA gene	Chr4:36623499-36624831 (+)
FVB/NJ	MGP_FVBNJ_G0003826	antisense lncRNA gene	Chr4:35972384-35973998 (+)
LP/J	MGP_LPJ_G0003887	antisense lncRNA gene	Chr4:38192331-38193558 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0003814	antisense lncRNA gene	Chr4:44264430-44266663 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0003995	antisense lncRNA gene	Chr4:37729862-37731235 (+)
PWK/PhJ	MGP_PWKPhJ_G0003719	antisense lncRNA gene	Chr4:36610605-36611973 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0003664	antisense lncRNA gene	Chr4:37468040-37469323 (+)
WSB/EiJ	MGP_WSBEiJ_G0003799	antisense lncRNA gene	Chr4:37726864-37728249 (+)

Homology

• Human Ortholog
  SMIM27, small integral membrane protein 27

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SMIM27, small integral membrane protein 27
  
• Synonyms
  C9orf133, TOPORS-AS1
• Links
  HGNC:31420

  NCBI Gene ID: 100129250

  UniProt: A0A1B0GUW7

  
  
• Chr Location
  9p21.1; chr9:32551144-32568621 (+)  GRCh38

---

• MGI Vertebrate Homology
  Smim27 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: SMIM27
• Gene Tree
  Smim27
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  20
• Chemically and radiation induced
  1
• Gene trapped
  19
• Genomic Mutations
  1 involving Smim27
• Find Mice (IMSR)
  8 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS89727.1

• Ensembl
  ENSMUSG00000028407 (Evidence)
• NCBI Gene
  100504309

Representative Sequences			Length	Strain/Species
genomic	100504309	NCBI Gene Model | MGI Sequence Detail	650	C57BL/6J
transcript	NM_001349093	RefSeq | MGI Sequence Detail	351	ZRU/MplStud
polypeptide	A0A140LHV9	UniProt | EBI | MGI Sequence Detail	49	Not Applicable

Protein
Information

• UniProt
  2 Sequences

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:5908856

References

• Summaries
  All 18

  Gene Ontology 1

  Phenotypes 4
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

TSS for Smim27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36803	Chr4:40269563-40269595 (+)	0 bp
Tssr36804	Chr4:40269887-40269911 (+)	320 bp
Tssr36805	Chr4:40269915-40269956 (+)	357 bp