Ddit3 MGI Mouse Gene Detail - MGI:109247 - DNA-damage inducible transcript 3

Symbol

Ddit3
Name

DNA-damage inducible transcript 3
Synonyms

C/EBP homoologous protein 10, chop, CHOP-10, CHOP10, gadd153

Feature Type

protein coding gene
IDs

MGI:109247
NCBI Gene: 13198
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:127126662-127132160 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM
Mapping Data

2 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109247	protein coding gene	Chr10:127126643-127132160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017816	protein coding gene	Chr10:130881140-130886654 (+)
A/J	MGP_AJ_G0017791	protein coding gene	Chr10:125636133-125641647 (+)
AKR/J	MGP_AKRJ_G0017754	protein coding gene	Chr10:129352173-129357685 (+)
BALB/cJ	MGP_BALBcJ_G0017755	protein coding gene	Chr10:126047933-126053447 (+)
C3H/HeJ	MGP_C3HHeJ_G0017579	protein coding gene	Chr10:129503336-129508849 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018210	protein coding gene	Chr10:135316972-135322486 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015890	protein coding gene	Chr10:119644979-119650289 (+)
CAST/EiJ	MGP_CASTEiJ_G0017139	protein coding gene	Chr10:130162163-130167581 (+)
CBA/J	MGP_CBAJ_G0017548	protein coding gene	Chr10:140768469-140773982 (+)
DBA/2J	MGP_DBA2J_G0017654	protein coding gene	Chr10:124728605-124734120 (+)
FVB/NJ	MGP_FVBNJ_G0017649	protein coding gene	Chr10:123669216-123674731 (+)
LP/J	MGP_LPJ_G0017728	protein coding gene	Chr10:131451327-131456842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017677	protein coding gene	Chr10:143471952-143477467 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018250	protein coding gene	Chr10:129416871-129422385 (+)
PWK/PhJ	MGP_PWKPhJ_G0016924	protein coding gene	Chr10:124931777-124937259 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016716	protein coding gene	Chr10:128455853-128461251 (+)
WSB/EiJ	MGP_WSBEiJ_G0017200	protein coding gene	Chr10:129647069-129652583 (+)

Human Ortholog

DDIT3, DNA damage inducible transcript 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDIT3, DNA damage inducible transcript 3
Synonyms

AltDDIT3, CEBPZ, C/EBPzeta, CHOP, CHOP-10, CHOP10, GADD153
Links

HGNC:2726

NCBI Gene ID: 1649

neXtProt AC: NX_P35638

UniProt: P0DPQ6, P35638
Chr Location

12q13.3; chr12:57516588-57521737 (-) GRCh38

MGI Vertebrate Homology

Ddit3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDIT3
Protein SuperFamily

C/EBPzeta_CHOP_DDIT3

Diseases

1 with human DDIT3 associations

				Human Disease	Mouse Models
				myxoid liposarcoma IDs myxoid liposarcoma DOID:5363 MESH:D018208 OMIM:613488 ORDO:99967 UMLS_CUI:C0206634

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 4 alleles in 8 genetic backgrounds
12 phenotypes from multigenic genotypes
169 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

4
Gene trapped

10
Targeted

8
Transgenic

1
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.

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All GO Annotations

154
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

374
Tissues

212
cDNA Data

52
Literature Summary

95

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddit3

ZFIN ddit3

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All Sequences

50
RefSeq

10
UniProt

4
CCDS

CCDS24236.1

Ensembl

ENSMUSG00000025408 (Evidence), ENSMUSG00000116429 (Evidence)
NCBI Gene

13198

			Length	Strain/Species	Flank
genomic	13198	NCBI Gene Model \| MGI Sequence Detail	5499	C57BL/6J	± kb
transcript	NM_001428454	RefSeq \| MGI Sequence Detail	975	C57BL/6
polypeptide	P35639	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006347 DNA damage-inducible transcript 3 protein

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR016670 DNA damage-inducible transcript 3

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All nucleic 64

Genomic 1

cDNA 53

Primer pair 10

Microarray probesets 3

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MGD-MRK-38292

Summaries

All 353

Developmental Gene Expression 95

Gene Ontology 31

Phenotypes 169
Earliest

J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
Latest

J:356241 Germani S, et al., SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. Cell Rep Med. 2024 Mar 19;5(3):101439

TSS for Ddit3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96179	Chr10:127125872-127125883 (+)	-784 bp
Tssr96180	Chr10:127126655-127126672 (+)	2 bp
Tssr96181	Chr10:127131313-127131317 (+)	4,653 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24