Fcmr MGI Mouse Gene Detail - MGI:1916419 - Fc fragment of IgM receptor

Symbol

Fcmr
Name

Fc fragment of IgM receptor
Synonyms

1810037B05Rik, Faim3, FcmuR

Feature Type

protein coding gene
IDs

MGI:1916419
NCBI Gene: 69169
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:130793514-130808528 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

449 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916419	protein coding gene	Chr1:130793406-130808528 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016443	protein coding gene	Chr1:134270063-134286463 (+)
A/J	MGP_AJ_G0016426	protein coding gene	Chr1:129300274-129315277 (+)
AKR/J	MGP_AKRJ_G0016391	protein coding gene	Chr1:133104678-133121861 (+)
BALB/cJ	MGP_BALBcJ_G0016386	protein coding gene	Chr1:129631440-129646766 (+)
C3H/HeJ	MGP_C3HHeJ_G0016212	protein coding gene	Chr1:133248167-133263117 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016847	protein coding gene	Chr1:139267276-139282244 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014561	protein coding gene	Chr1:122444873-122460118 (+)
CAST/EiJ	MGP_CASTEiJ_G0015792	protein coding gene	Chr1:132239422-132255364 (+)
CBA/J	MGP_CBAJ_G0016184	protein coding gene	Chr1:144069250-144084249 (+)
DBA/2J	MGP_DBA2J_G0016291	protein coding gene	Chr1:128262684-128277677 (+)
FVB/NJ	MGP_FVBNJ_G0016290	protein coding gene	Chr1:126905561-126922232 (+)
LP/J	MGP_LPJ_G0016362	protein coding gene	Chr1:135579417-135595674 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016315	protein coding gene	Chr1:149830606-149847571 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016883	protein coding gene	Chr1:132866911-132883050 (+)
PWK/PhJ	MGP_PWKPhJ_G0015578	protein coding gene	Chr1:127236062-127251099 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015365	protein coding gene	Chr1:131805670-131823957 (+)
WSB/EiJ	MGP_WSBEiJ_G0015854	protein coding gene	Chr1:132841348-132856501 (+)

Human Ortholog

FCMR, Fc mu receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCMR, Fc mu receptor
Synonyms

FAIM3, FcmuR, IgM FcR, TOSO
Links

HGNC:14315

NCBI Gene ID: 9214

neXtProt AC: NX_O60667

UniProt: O60667
Chr Location

1q32.1; chr1:206903317-206923247 (-) GRCh38

MGI Vertebrate Homology

Fcmr stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FCMR
Gene Tree

Fcmr

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Phenotype Summary

29 phenotypes from 4 alleles in 4 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

4
Radiation induced

1
Targeted

8
Genomic Mutations

3 involving Fcmr
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

4
UniProt

3
CCDS

CCDS15261.1

Ensembl

ENSMUSG00000042474 (Evidence)
NCBI Gene

69169

			Length	Strain/Species	Flank
genomic	69169	NCBI Gene Model \| MGI Sequence Detail	15015	C57BL/6J	± kb
transcript	NM_026976	RefSeq \| MGI Sequence Detail	1492	C57BL/6
polypeptide	A1KXC4	UniProt \| EBI \| MGI Sequence Detail	422	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007329 immunoglobulin mu Fc receptor

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain
GlyGen

A1KXC4 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 3

Summaries

All 59

Gene Ontology 8

Phenotypes 30
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10

TSS for Fcmr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8600	Chr1:130793483-130793505 (+)	-20 bp
Tssr8601	Chr1:130793507-130793522 (+)	1 bp
Tssr8602	Chr1:130793524-130793541 (+)	19 bp
Tssr8603	Chr1:130793793-130793809 (+)	287 bp
Tssr8604	Chr1:130801902-130801908 (+)	8,391 bp
Tssr8605	Chr1:130801963-130801974 (+)	8,455 bp
Tssr8606	Chr1:130802062-130802070 (+)	8,552 bp
Tssr8607	Chr1:130803719-130803745 (+)	10,218 bp
Tssr8608	Chr1:130805525-130805537 (+)	12,017 bp
Tssr8609	Chr1:130806064-130806077 (+)	12,557 bp
Tssr8610	Chr1:130806083-130806096 (+)	12,576 bp
Tssr8611	Chr1:130806157-130806179 (+)	12,654 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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