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Nlrp1b Gene Detail
Summary
  • Symbol
    Nlrp1b
  • Name
    NLR family, pyrin domain containing 1B
  • Synonyms
    Nalp1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3582959
    NCBI Gene: 637515
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:71043928-71121559 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1654 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3582959
 protein coding gene Chr11:71043400-71133340 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018625
 protein coding gene Chr11:71718320-71837153 (-)
A/J MGP_AJ_G0018593
 protein coding gene Chr11:69010021-69063787 (-)
AKR/J MGP_AKRJ_G0018562
 protein coding gene Chr11:71069971-71264277 (-)
BALB/cJ MGP_BALBcJ_G0018565
 protein coding gene Chr11:69309187-69353860 (-)
C3H/HeJ MGP_C3HHeJ_G0018378
 protein coding gene Chr11:71114744-71156284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019016
 protein coding gene Chr11:73907971-73975267 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0017933
 protein coding gene Chr11:71377943-71471995 (-)
CBA/J MGP_CBAJ_G0018350
 protein coding gene Chr11:77230585-77267345 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0018450
 protein coding gene Chr11:68212515-68331891 (-)
LP/J MGP_LPJ_G0018530
 protein coding gene Chr11:72310455-72346765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018473
 protein coding gene Chr11:77765787-77806304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019058
 protein coding gene Chr11:71329491-71369040 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017496
 protein coding gene Chr11:71088979-71122955 (-)
WSB/EiJ MGP_WSBEiJ_G0017987
 protein coding gene Chr11:70999472-71142543 (-)



Homology
more
  • Human Ortholog
    NLRP1, NLR family pyrin domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP1, NLR family pyrin domain containing 1
  • Synonyms
    AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, JRRP, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1
  • Links
    NCBI Gene ID: 22861
    neXtProt AC: NX_Q9C000
    UniProt: Q9C000

  • Chr Location
    17p13.2; chr17:5499415-5619424 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NLRP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070390 Ensembl Gene Model | MGI Sequence Detail 77632 C57BL/6J ±  kb
transcript ENSMUST00000108515 Ensembl | MGI Sequence Detail 4131 Not Applicable  
polypeptide ENSMUSP00000104155 Ensembl | MGI Sequence Detail 1177 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:3641853, MGI:3712674
References
more
  • Summaries
    All 52
    Gene Ontology 4
    Phenotypes 36
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:348863 Kumar SRP, et al., TLR9-independent CD8(+) T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. Mol Ther. 2024 Feb 7;32(2):325-339
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory