About   Help   FAQ
L3mbtl1 Gene Detail
Summary
  • Symbol
    L3mbtl1
  • Name
    L3MBTL1 histone methyl-lysine binding protein
  • Synonyms
    L3MBTL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676663
    NCBI Gene: 241764
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:162785392-162816442 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 83.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676663
protein coding gene Chr2:162784260-162819726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026814
protein coding gene Chr2:168222629-168258772 (+)
A/J MGP_AJ_G0026780
protein coding gene Chr2:161478720-161509926 (+)
AKR/J MGP_AKRJ_G0026751
protein coding gene Chr2:166236894-166269910 (+)
BALB/cJ MGP_BALBcJ_G0026789
protein coding gene Chr2:161797492-161828997 (+)
C3H/HeJ MGP_C3HHeJ_G0026531
protein coding gene Chr2:166584774-166619835 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027237
protein coding gene Chr2:173171113-173204963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024607
protein coding gene Chr2:154771234-154803419 (+)
CAST/EiJ MGP_CASTEiJ_G0025992
protein coding gene Chr2:166943078-166977359 (+)
CBA/J MGP_CBAJ_G0026508
protein coding gene Chr2:179428293-179470033 (+)
DBA/2J MGP_DBA2J_G0026646
protein coding gene Chr2:160647523-160679383 (+)
FVB/NJ MGP_FVBNJ_G0026612
protein coding gene Chr2:159016315-159047651 (+)
LP/J MGP_LPJ_G0026749
protein coding gene Chr2:168374002-168407171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026634
protein coding gene Chr2:183116983-183149779 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027293
protein coding gene Chr2:166117589-166157648 (+)
PWK/PhJ MGP_PWKPhJ_G0025726
protein coding gene Chr2:160195249-160226701 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025529
protein coding gene Chr2:164990361-165023258 (+)
WSB/EiJ MGP_WSBEiJ_G0026062
protein coding gene Chr2:166987479-167022496 (+)



Homology
more
  • Human Ortholog
    L3MBTL1, L3MBTL histone methyl-lysine binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    L3MBTL1, L3MBTL histone methyl-lysine binding protein 1
  • Synonyms
    dJ138B7.3, H-L(3)MBT, L3MBTL, ZC2HC3
  • Links
    NCBI Gene ID: 26013
    neXtProt AC: NX_Q9Y468
    UniProt: Q9Y468

  • Chr Location
    20q13.12; chr20:43489442-43550954 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele exhibit normal nervous system phenotype, hematopoietic system phenotype, immune system phenotype, cellular phenotype, and lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035576 Ensembl Gene Model | MGI Sequence Detail 31051 C57BL/6J ±  kb
transcript ENSMUST00000035751 Ensembl | MGI Sequence Detail 2724 Not Applicable  
polypeptide ENSMUSP00000044038 Ensembl | MGI Sequence Detail 826 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000009640 lethal(3)malignant brain tumor-like protein 1
  • InterPro Domains
    IPR047361 Lethal(3)malignant brain tumor-like protein 1, first MBT repeat
    IPR047362 Lethal(3)malignant brain tumor-like protein 1, third MBT repeat
    IPR004092 Mbt repeat
    IPR050548 Polycomb group and chromatin remodeling factors
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
    IPR002515 Zinc finger, C2H2C-type
    IPR036060 Zinc finger, C2H2C-type superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:270691 Mao W, et al., Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1. Cell Rep. 2018 Jun 12;23(11):3209-3222

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory