Fbf1 MGI Mouse Gene Detail - MGI:1922033

Symbol

Fbf1
Name

Fas binding factor 1
Synonyms

1110033G01Rik, mKIAA1863

Feature Type

protein coding gene
IDs

MGI:1922033
NCBI Gene: 217335
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:116033111-116058992 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.93 cM
Mapping Data

1 experiment

SNPs within 2kb

896 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922033	protein coding gene	Chr11:116033111-116059097 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019417	protein coding gene	Chr11:120232101-120257978 (-)
A/J	MGP_AJ_G0019386	protein coding gene	Chr11:114980027-115006130 (-)
AKR/J	MGP_AKRJ_G0019356	protein coding gene	Chr11:118405783-118431689 (-)
BALB/cJ	MGP_BALBcJ_G0019360	protein coding gene	Chr11:115389541-115415491 (-)
C3H/HeJ	MGP_C3HHeJ_G0019166	protein coding gene	Chr11:118760429-118786336 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019810	protein coding gene	Chr11:123920337-123946190 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017433	protein coding gene	Chr11:111992719-112017501 (-)
CAST/EiJ	MGP_CASTEiJ_G0018721	protein coding gene	Chr11:120115751-120141690 (-)
CBA/J	MGP_CBAJ_G0019138	protein coding gene	Chr11:128803863-128829772 (-)
DBA/2J	MGP_DBA2J_G0019249	protein coding gene	Chr11:114395357-114422449 (-)
FVB/NJ	MGP_FVBNJ_G0019241	protein coding gene	Chr11:113912281-113938126 (-)
LP/J	MGP_LPJ_G0019319	protein coding gene	Chr11:120612927-120638828 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019274	protein coding gene	Chr11:127894965-127920804 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019848	protein coding gene	Chr11:119066427-119092268 (-)
PWK/PhJ	MGP_PWKPhJ_G0018485	protein coding gene	Chr11:115732257-115759061 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018278	protein coding gene	Chr11:118819387-118845325 (-)
WSB/EiJ	MGP_WSBEiJ_G0018773	protein coding gene	Chr11:119030900-119056773 (-)

Human Ortholog

FBF1, Fas binding factor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBF1, Fas binding factor 1
Synonyms

Alb, FBF-1
Links

HGNC:24674

NCBI Gene ID: 85302

neXtProt AC: NX_Q8TES7

UniProt: Q8TES7
Chr Location

17q25.1; chr17:75909574-75941140 (-) GRCh38

MGI Vertebrate Homology

Fbf1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FBF1
Gene Tree

Fbf1

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

82
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbf1

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All Sequences

101
RefSeq

45
UniProt

5
CCDS

CCDS25659.1

Ensembl

ENSMUSG00000020776 (Evidence)
NCBI Gene

217335

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020776	Ensembl Gene Model \| MGI Sequence Detail	25882	C57BL/6J	± kb
transcript	ENSMUST00000103031	Ensembl \| MGI Sequence Detail	5252	Not Applicable
polypeptide	ENSMUSP00000099320	Ensembl \| MGI Sequence Detail	1173	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007355 Fas-binding factor 1

(term hierarchy)
InterPro Domains

IPR033561 Fas-binding factor 1

IPR049390 Fas-binding factor 1, C-terminal

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All nucleic 85

Genomic 2

cDNA 82

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111865	Chr11:116059121-116059132 (-)	-135 bp
Tssr111864	Chr11:116058964-116059031 (-)	-6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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