Tmem201 MGI Mouse Gene Detail - MGI:1196277

Symbol

Tmem201
Name

transmembrane protein 201
Synonyms

D4Ertd429e, Samp1

Feature Type

protein coding gene
IDs

MGI:1196277
NCBI Gene: 230917
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:149799832-149822501 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 80.15 cM
Mapping Data

2 experiments

SNPs within 2kb

4 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196277	protein coding gene	Chr4:149799832-149822501 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029145	protein coding gene	Chr4:153616455-153639143 (-)
A/J	MGP_AJ_G0029110	protein coding gene	Chr4:147180500-147203380 (-)
AKR/J	MGP_AKRJ_G0029058	protein coding gene	Chr4:151221992-151244663 (-)
BALB/cJ	MGP_BALBcJ_G0029126	protein coding gene	Chr4:147681845-147704508 (-)
C3H/HeJ	MGP_C3HHeJ_G0028847	protein coding gene	Chr4:151768206-151790862 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029575	protein coding gene	Chr4:159149333-159171998 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026821	protein coding gene	Chr4:139597186-139619653 (-)
CAST/EiJ	MGP_CASTEiJ_G0028260	protein coding gene	Chr4:149017171-149042615 (-)
CBA/J	MGP_CBAJ_G0028809	protein coding gene	Chr4:163804839-163827491 (-)
DBA/2J	MGP_DBA2J_G0028958	protein coding gene	Chr4:147273935-147296586 (-)
FVB/NJ	MGP_FVBNJ_G0028922	protein coding gene	Chr4:146406370-146432491 (-)
LP/J	MGP_LPJ_G0029048	protein coding gene	Chr4:153528949-153551593 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028949	protein coding gene	Chr4:167032320-167055753 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029607	protein coding gene	Chr4:151714297-151737628 (-)
PWK/PhJ	MGP_PWKPhJ_G0027980	protein coding gene	Chr4:143292725-143315948 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027814	protein coding gene	Chr4:145971394-145993190 (-)
WSB/EiJ	MGP_WSBEiJ_G0028340	protein coding gene	Chr4:151866183-151888857 (-)

Human Ortholog

TMEM201, transmembrane protein 201

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM201, transmembrane protein 201
Synonyms

Ima1, NET5, SAMP1
Links

HGNC:33719

NCBI Gene ID: 199953

neXtProt AC: NX_Q5SNT2

UniProt: Q5SNT2
Chr Location

1p36.22; chr1:9588911-9614877 (+) GRCh38

MGI Vertebrate Homology

Tmem201 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM201
Gene Tree

Tmem201

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Tmem201
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a null allele display impaired angiogenesis.

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All GO Annotations

20
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

62

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tmem201

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All Sequences

83
RefSeq

21
UniProt

4
CCDS

CCDS18964.1, CCDS18965.1, CCDS71523.1

Ensembl

ENSMUSG00000044700 (Evidence)
NCBI Gene

230917

			Length	Strain/Species	Flank
genomic	230917	NCBI Gene Model \| MGI Sequence Detail	22670	C57BL/6J	± kb
transcript	NM_001426160	RefSeq \| MGI Sequence Detail	3815	C57BL/6
polypeptide	A2A8U2	UniProt \| EBI \| MGI Sequence Detail	664	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029803 transmembrane protein 201

(term hierarchy)
InterPro Domains

IPR018617 Ima1, N-terminal domain

IPR040041 Transmembrane protein 201

IPR018861 Transmembrane protein 201, C-terminal
GlyGen

A2A8U2 1 site, 1 O-linked glycan (1 site)

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All nucleic 63

cDNA 62

Primer pair 1

Microarray probesets 6

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MGI:2140517

Summaries

All 37

Gene Ontology 4

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:342229 Zhang Y, et al., Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex. J Mol Cell Biol. 2022 Jul 14;14(3)

TSS for Tmem201:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44681	Chr4:149822512-149822534 (-)	-22 bp
Tssr44680	Chr4:149822414-149822511 (-)	38 bp
Tssr44679	Chr4:149800231-149800235 (-)	22,268 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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