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Prdm16 Gene Detail
Summary
  • Symbol
    Prdm16
  • Name
    PR domain containing 16
  • Synonyms
    5730557K01Rik, csp1, line 27, Mel1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917923
    NCBI Gene: 70673
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154400582-154721330 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.96 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8064 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917923
 protein coding gene Chr4:154400579-154721851 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029196
 protein coding gene Chr4:158583722-158921746 (-)
A/J MGP_AJ_G0029161
 protein coding gene Chr4:151923524-152247720 (-)
AKR/J MGP_AKRJ_G0029109
 protein coding gene Chr4:156075220-156402446 (-)
BALB/cJ MGP_BALBcJ_G0029177
 protein coding gene Chr4:152393841-152717167 (-)
C3H/HeJ MGP_C3HHeJ_G0028898
 protein coding gene Chr4:156607675-156940002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029626
 protein coding gene Chr4:164248143-164590430 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026872
 protein coding gene Chr4:144227428-144547814 (-)
CAST/EiJ MGP_CASTEiJ_G0028311
 protein coding gene Chr4:154016739-154356188 (-)
CBA/J MGP_CBAJ_G0028860
 protein coding gene Chr4:169183165-169536285 (-)
DBA/2J MGP_DBA2J_G0029009
 protein coding gene Chr4:151952446-152275395 (-)
FVB/NJ MGP_FVBNJ_G0028973
 protein coding gene Chr4:151158675-151487428 (-)
LP/J MGP_LPJ_G0029099
 protein coding gene Chr4:158494870-158838197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029000
 protein coding gene Chr4:172096685-172428412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029658
 protein coding gene Chr4:156635756-156982774 (-)
PWK/PhJ MGP_PWKPhJ_G0028031
 protein coding gene Chr4:148045196-148381886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027865
 protein coding gene Chr4:150939172-151271801 (-)
WSB/EiJ MGP_WSBEiJ_G0028391
 protein coding gene Chr4:156810404-157146398 (-)



Homology
more
  • Human Ortholog
    PRDM16, PR/SET domain 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM16, PR/SET domain 16
  • Synonyms
    CMD1LL, KMT8F, LVNC8, MEL1, PFM13
  • Links
    NCBI Gene ID: 63976
    neXtProt AC: NX_Q9HAZ2
    UniProt: Q9HAZ2

  • Chr Location
    1p36.32; chr1:3069168-3438621 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prdm16 mouse models; 1 with human PRDM16 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    83 phenotypes from 3 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice exhibit a cleft secondary palate, whitening of brown adipose tissue in older or fed a high-fat diet, and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1052
  • Tissues
    252
  • cDNA Data
    35
  • Literature Summary
    68
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039410 Ensembl Gene Model | MGI Sequence Detail 320749 C57BL/6J ±  kb
    transcript ENSMUST00000105638 Ensembl | MGI Sequence Detail 8601 Not Applicable  
    polypeptide ENSMUSP00000101263 Ensembl | MGI Sequence Detail 1276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 35
      Primer pair 11
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3576005
    References
    more
    • Summaries
      All 175
      Developmental Gene Expression 68
      Diseases 1
      Gene Ontology 21
      Phenotypes 72
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354288 Young CA, et al., A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2. Development. 2024 Sep 1;151(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory