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Mageb4 Gene Detail
Summary
  • Symbol
    Mageb4
  • Name
    MAGE family member B4
  • Synonyms
    CN716893, Mage-b4, mMage-b4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148568
    NCBI Gene: 434903
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:85293862-85299825 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 39.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148568
 protein coding gene ChrX:85293860-85348699 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0035878
 protein coding gene ChrX:82495846-82501745 (-)
AKR/J MGP_AKRJ_G0035796
 protein coding gene ChrX:84654234-84718729 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0035569
 protein coding gene ChrX:82643012-82649157 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0033221
 protein coding gene ChrX:81315731-81317032 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0035544
 protein coding gene ChrX:87171688-87177262 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0035638
 protein coding gene ChrX:81248009-81256186 (-)
LP/J MGP_LPJ_G0035788
 protein coding gene ChrX:83146105-83157471 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034386
 protein coding gene ChrX:68544034-68548996 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MAGEB1, MAGE family member B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEB1, MAGE family member B1
  • Synonyms
    CT3.1, DAM10, MAGEL1, MAGE-Xp
  • Links
    NCBI Gene ID: 4112
    neXtProt AC: NX_P43366
    UniProt: P43366

  • Chr Location
    Xp21.2; chrX:30243715-30252040 (+)  GRCh38
  • Human Ortholog
    MAGEB2, MAGE family member B2
  • Synonyms
    CT3.2, DAM6, MAGE-XP-2
  • Links
    NCBI Gene ID: 4113
    neXtProt AC: NX_O15479
    UniProt: O15479

  • Chr Location
    Xp21.2; chrX:30215563-30220089 (+)  GRCh38
  • Human Ortholog
    MAGEB4, MAGE family member B4
  • Synonyms
    CT3.6
  • Links
    NCBI Gene ID: 4115
    neXtProt AC: NX_O15481
    UniProt: O15481

  • Chr Location
    Xp21.2; chrX:30242000-30244187 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    36
  • cDNA Data
    10
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 434903 NCBI Gene Model | MGI Sequence Detail 5964 C57BL/6J ±  kb
    transcript NM_001033492 RefSeq | MGI Sequence Detail 2401 C57BL/6  
    polypeptide A2A9R3 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR002190 MAGE homology domain
      IPR041898 MAGE homology domain, winged helix WH1 motif
      IPR041899 MAGE homology domain, winged helix WH2 motif
      IPR037445 Melanoma-associated antigen
      IPR021072 Melanoma associated antigen, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3584456
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 13
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:70948 Osterlund C, et al., Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation. Cancer Res. 2000 Feb 15;60(4):1054-61
    • Latest
      J:338693 Li N, et al., MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice. Biochem Biophys Res Commun. 2023 Jul 10;675:46-53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory