Meioc MGI Mouse Gene Detail - MGI:2686410 - meiosis specific with coiled-coil domain

Symbol

Meioc
Name

meiosis specific with coiled-coil domain
Synonyms

Gm1564, LOC268491, LOC380729

Feature Type

protein coding gene
IDs

MGI:2686410
NCBI Gene: 268491
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:102556177-102573066 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.48 cM
Mapping Data

1 experiment

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686410	protein coding gene	Chr11:102554542-102573066 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019241	protein coding gene	Chr11:105668970-105689616 (+)
A/J	MGP_AJ_G0019209	protein coding gene	Chr11:101198121-101216710 (+)
AKR/J	MGP_AKRJ_G0019178	protein coding gene	Chr11:104334975-104353496 (+)
BALB/cJ	MGP_BALBcJ_G0019183	protein coding gene	Chr11:101680754-101699550 (+)
C3H/HeJ	MGP_C3HHeJ_G0018992	protein coding gene	Chr11:104536824-104555285 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019632	protein coding gene	Chr11:108954695-108975225 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017258	protein coding gene	Chr11:98626669-98648484 (+)
CAST/EiJ	MGP_CASTEiJ_G0018546	protein coding gene	Chr11:105540465-105560481 (+)
CBA/J	MGP_CBAJ_G0018961	protein coding gene	Chr11:113449554-113472097 (+)
DBA/2J	MGP_DBA2J_G0019073	protein coding gene	Chr11:100713577-100731991 (+)
FVB/NJ	MGP_FVBNJ_G0019063	protein coding gene	Chr11:100255899-100274284 (+)
LP/J	MGP_LPJ_G0019142	protein coding gene	Chr11:106193025-106213046 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019094	protein coding gene	Chr11:112930885-112948833 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019670	protein coding gene	Chr11:104694249-104723232 (+)
PWK/PhJ	MGP_PWKPhJ_G0018309	protein coding gene	Chr11:101782042-101811491 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018101	protein coding gene	Chr11:104458429-104476841 (+)
WSB/EiJ	MGP_WSBEiJ_G0018595	protein coding gene	Chr11:104695634-104717283 (+)

Human Ortholog

MEIOC, meiosis specific with coiled-coil domain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEIOC, meiosis specific with coiled-coil domain
Synonyms

C17orf104
Links

HGNC:26670

NCBI Gene ID: 284071

neXtProt AC: NX_A2RUB1

UniProt: A2RUB1
Chr Location

17q21.31; chr17:44656404-44690308 (+) GRCh38

MGI Vertebrate Homology

Meioc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEIOC
Gene Tree

Meioc

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

1 involving Meioc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis.

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

42
cDNA Data

12
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

7
UniProt

2
CCDS

CCDS48945.1

Ensembl

ENSMUSG00000051455 (Evidence)
NCBI Gene

268491

			Length	Strain/Species	Flank
genomic	268491	NCBI Gene Model \| MGI Sequence Detail	16890	C57BL/6J	± kb
transcript	NM_001127576	RefSeq \| MGI Sequence Detail	4577	C57BL/6
polypeptide	A2AG06	UniProt \| EBI \| MGI Sequence Detail	965	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059681 meiosis-specific coiled-coil domain-containing protein MEIOC

(term hierarchy)
InterPro Domains

IPR027963 Meiosis-specific coiled-coil domain-containing protein MEIOC

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All nucleic 17

Genomic 2

cDNA 12

Primer pair 3

Microarray probesets 2

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MGI:2685509

Summaries

All 36

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 12
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:352963 Pfaltzgraff NG, et al., Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells. Development. 2024 Jul 15;151(14)

TSS for Meioc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105279	Chr11:102556360-102556386 (+)	196 bp
Tssr105280	Chr11:102556392-102556421 (+)	230 bp
Tssr105281	Chr11:102556438-102556459 (+)	272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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