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Mllt3 Gene Detail
Summary
  • Symbol
    Mllt3
  • Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
  • Synonyms
    2210011H10Rik, 2610012I03Rik, 3830408D16Rik, Af9, D4Ertd321e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917372
    NCBI Gene: 70122
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:87688162-87951601 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 41.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917372
 protein coding gene Chr4:87688162-87951652 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028418
 protein coding gene Chr4:87602483-87875262 (-)
A/J MGP_AJ_G0028379
 protein coding gene Chr4:84580496-84837583 (-)
AKR/J MGP_AKRJ_G0028328
 protein coding gene Chr4:86655668-86919843 (-)
BALB/cJ MGP_BALBcJ_G0028399
 protein coding gene Chr4:84780062-85040291 (-)
C3H/HeJ MGP_C3HHeJ_G0028114
 protein coding gene Chr4:87382865-87652912 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028838
 protein coding gene Chr4:90983575-91261585 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026138
 protein coding gene Chr4:80585108-80846828 (-)
CAST/EiJ MGP_CASTEiJ_G0027555
 protein coding gene Chr4:85225784-85505395 (-)
CBA/J MGP_CBAJ_G0028083
 protein coding gene Chr4:93781830-94073459 (-)
DBA/2J MGP_DBA2J_G0028232
 protein coding gene Chr4:84328336-84586303 (-)
FVB/NJ MGP_FVBNJ_G0028198
 protein coding gene Chr4:83285880-83543928 (-)
LP/J MGP_LPJ_G0028332
 protein coding gene Chr4:87958819-88234160 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028227
 protein coding gene Chr4:98785453-99059794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028875
 protein coding gene Chr4:86790072-87055514 (-)
PWK/PhJ MGP_PWKPhJ_G0027278
 protein coding gene Chr4:82668696-82931549 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027103
 protein coding gene Chr4:84282184-84557742 (-)
WSB/EiJ MGP_WSBEiJ_G0027631
 protein coding gene Chr4:87002760-87275672 (-)



Homology
more
  • Human Ortholog
    MLLT3, MLLT3 super elongation complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLLT3, MLLT3 super elongation complex subunit
  • Synonyms
    AF9, YEATS3
  • Links
    NCBI Gene ID: 4300
    neXtProt AC: NX_P42568
    UniProt: P42568

  • Chr Location
    9p21.3; chr9:20341669-20622499 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 50% of homozygous null mice die perinatally while the remaining 50% become runted and die within two weeks of birth with severe defects of the axial skeleton, including anterior homeotic transformation of the cervical and thoracic regions, a deformed atlas and an extra cervical vertebra.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1170
  • Tissues
    158
  • cDNA Data
    21
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028496 Ensembl Gene Model | MGI Sequence Detail 263440 C57BL/6J ±  kb
    transcript ENSMUST00000078090 Ensembl | MGI Sequence Detail 6069 Not Applicable  
    polypeptide ENSMUSP00000077232 Ensembl | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 2
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1196448, MGI:1919694, MGI:1924826
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory