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Fmnl2 Gene Detail
Summary
  • Symbol
    Fmnl2
  • Name
    formin-like 2
  • Synonyms
    5430425K04Rik, man
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918659
    NCBI Gene: 71409
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:52747872-53023816 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 30.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7633 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918659
 protein coding gene Chr2:52747743-53023816 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025737
 protein coding gene Chr2:52227979-52522841 (+)
A/J MGP_AJ_G0025713
 protein coding gene Chr2:50201723-50480872 (+)
AKR/J MGP_AKRJ_G0025683
 protein coding gene Chr2:51633469-51925855 (+)
BALB/cJ MGP_BALBcJ_G0025708
 protein coding gene Chr2:50305761-50585731 (+)
C3H/HeJ MGP_C3HHeJ_G0025469
 protein coding gene Chr2:51655422-51950258 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026154
 protein coding gene Chr2:53754447-54047557 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023560
 protein coding gene Chr2:48170956-48450802 (+)
CAST/EiJ MGP_CASTEiJ_G0024934
 protein coding gene Chr2:51760325-52068315 (+)
CBA/J MGP_CBAJ_G0025449
 protein coding gene Chr2:55801482-56104771 (+)
DBA/2J MGP_DBA2J_G0025580
 protein coding gene Chr2:49845619-50127161 (+)
FVB/NJ MGP_FVBNJ_G0025542
 protein coding gene Chr2:49534216-49813970 (+)
LP/J MGP_LPJ_G0025668
 protein coding gene Chr2:52124679-52423111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025573
 protein coding gene Chr2:56799335-57101751 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026212
 protein coding gene Chr2:51572693-51860372 (+)
PWK/PhJ MGP_PWKPhJ_G0024675
 protein coding gene Chr2:49732694-50016239 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024481
 protein coding gene Chr2:51773268-52089767 (+)
WSB/EiJ MGP_WSBEiJ_G0025001
 protein coding gene Chr2:51850535-52149801 (+)



Homology
more
  • Human Ortholog
    FMNL2, formin like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FMNL2, formin like 2
  • Synonyms
    FHOD2
  • Links
    NCBI Gene ID: 114793
    neXtProt AC: NX_Q96PY5
    UniProt: Q96PY5

  • Chr Location
    2q23.3; chr2:152335174-152649826 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    3
  • cDNA Data
    67
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036053 Ensembl Gene Model | MGI Sequence Detail 275945 C57BL/6J ±  kb
    transcript ENSMUST00000090952 Ensembl | MGI Sequence Detail 5414 Not Applicable  
    polypeptide ENSMUSP00000088472 Ensembl | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 67
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory