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Itga8 Gene Detail
Summary
  • Symbol
    Itga8
  • Name
    integrin alpha 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109442
    NCBI Gene: 241226
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:12111443-12306733 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 9.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109442
 protein coding gene Chr2:12111443-12306755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025350
 protein coding gene Chr2:9543877-9742035 (-)
A/J MGP_AJ_G0025327
 protein coding gene Chr2:9178584-9379926 (-)
AKR/J MGP_AKRJ_G0025296
 protein coding gene Chr2:9451435-9654215 (-)
BALB/cJ MGP_BALBcJ_G0025323
 protein coding gene Chr2:9159397-9357809 (-)
C3H/HeJ MGP_C3HHeJ_G0025083
 protein coding gene Chr2:9412903-9609547 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025765
 protein coding gene Chr2:9794950-9998112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023180
 protein coding gene Chr2:8676245-8866635 (-)
CAST/EiJ MGP_CASTEiJ_G0024546
 protein coding gene Chr2:9362324-9566354 (-)
CBA/J MGP_CBAJ_G0025062
 protein coding gene Chr2:10220715-10432507 (-)
DBA/2J MGP_DBA2J_G0025194
 protein coding gene Chr2:9057717-9245786 (-)
FVB/NJ MGP_FVBNJ_G0025156
 protein coding gene Chr2:8985671-9180590 (-)
LP/J MGP_LPJ_G0025280
 protein coding gene Chr2:9450460-9647107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025188
 protein coding gene Chr2:10110797-10314603 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025823
 protein coding gene Chr2:9359410-9552867 (-)
PWK/PhJ MGP_PWKPhJ_G0024297
 protein coding gene Chr2:9001799-9200252 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024097
 protein coding gene Chr2:9371979-9568853 (-)
WSB/EiJ MGP_WSBEiJ_G0024616
 protein coding gene Chr2:9467490-9670002 (-)



Homology
more
  • Human Ortholog
    ITGA8, integrin subunit alpha 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA8, integrin subunit alpha 8
  • Links
    NCBI Gene ID: 8516
    neXtProt AC: NX_P53708
    UniProt: P53708

  • Chr Location
    10p13; chr10:15513954-15719922 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human ITGA8 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    60
  • cDNA Data
    49
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026768 Ensembl Gene Model | MGI Sequence Detail 195291 C57BL/6J ±  kb
    transcript ENSMUST00000028106 Ensembl | MGI Sequence Detail 5812 Not Applicable  
    polypeptide ENSMUSP00000028106 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009133 integrin alpha-8
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      A2ARA8 16 sites, 5 N-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 49
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38487, MGI:2138946
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 49
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory