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Ankrd16 Gene Detail
Summary
  • Symbol
    Ankrd16
  • Name
    ankyrin repeat domain 16
  • Synonyms
    2810455F06Rik, D430029B21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444796
    NCBI Gene: 320816
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:11782687-11795140 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 9.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    529 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444796
 protein coding gene Chr2:11781902-11795140 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025349
 protein coding gene Chr2:9208170-9220617 (+)
A/J MGP_AJ_G0025326
 protein coding gene Chr2:8819891-8837502 (+)
AKR/J MGP_AKRJ_G0025295
 protein coding gene Chr2:9132262-9145989 (+)
BALB/cJ MGP_BALBcJ_G0025322
 protein coding gene Chr2:8808553-8821427 (+)
C3H/HeJ MGP_C3HHeJ_G0025082
 protein coding gene Chr2:9037436-9049606 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025764
 protein coding gene Chr2:9458733-9477175 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023179
 protein coding gene Chr2:8246051-8259669 (+)
CAST/EiJ MGP_CASTEiJ_G0024545
 protein coding gene Chr2:9078688-9091183 (+)
CBA/J MGP_CBAJ_G0025061
 protein coding gene Chr2:9854652-9867105 (+)
DBA/2J MGP_DBA2J_G0025193
 protein coding gene Chr2:8730978-8744578 (+)
FVB/NJ MGP_FVBNJ_G0025155
 protein coding gene Chr2:8652208-8664661 (+)
LP/J MGP_LPJ_G0025279
 protein coding gene Chr2:9124282-9136506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025187
 protein coding gene Chr2:9732974-9754094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025822
 protein coding gene Chr2:9047690-9060048 (+)
PWK/PhJ MGP_PWKPhJ_G0024296
 protein coding gene Chr2:8710499-8723699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024096
 protein coding gene Chr2:9055065-9068703 (+)
WSB/EiJ MGP_WSBEiJ_G0024615
 protein coding gene Chr2:9114590-9126932 (+)



Homology
more
  • Human Ortholog
    ANKRD16, ankyrin repeat domain 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKRD16, ankyrin repeat domain 16
  • Links
    NCBI Gene ID: 54522
    neXtProt AC: NX_Q6P6B7
    UniProt: Q6P6B7

  • Chr Location
    10p15.1; chr10:5861616-5889906 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no obvious pathologies. The variant from CAST/Ei or CASA/RkJ suppresses the Aarssti phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    50
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047909 Ensembl Gene Model | MGI Sequence Detail 12454 C57BL/6J ±  kb
transcript ENSMUST00000056108 Ensembl | MGI Sequence Detail 1618 Not Applicable  
polypeptide ENSMUSP00000052056 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000032202 ankyrin repeat domain-containing protein 16
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR050776 Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR050842 Cul2-RING E3 Ligase Substrate-Recognition Fem-1
    IPR050889 Dendritic Spine Regulation and Scaffold
    IPR051165 Multifunctional Ankyrin Repeat Domain-Containing Protein
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920083, MGI:2139025
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:262421 Vo MN, et al., ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Nature. 2018 May;557(7706):510-515
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory