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Ttll2 Gene Detail
Summary
  • Symbol
    Ttll2
  • Name
    tubulin tyrosine ligase-like family, member 2
  • Synonyms
    EG625850
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644030
    NCBI Gene: 100216474
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:7618284-7620095 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644030
 protein coding gene Chr17:7618026-7631434 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023119
 protein coding gene Chr17:4623258-4624980 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0023094
 protein coding gene Chr17:4669136-4670928 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023534
 protein coding gene Chr17:4886921-4888713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021075
 protein coding gene Chr17:9089010-9090799 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022822
 protein coding gene Chr17:5095330-5097122 (-)
DBA/2J MGP_DBA2J_G0022994
 protein coding gene Chr17:10262053-10263845 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0023026
 protein coding gene Chr17:4877126-4881456 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0023599
 protein coding gene Chr17:10741896-10743689 (-)
PWK/PhJ MGP_PWKPhJ_G0022113
 protein coding gene Chr17:4114083-4115876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021943
 protein coding gene Chr17:4455329-4457121 (+)
WSB/EiJ MGP_WSBEiJ_G0022421
 protein coding gene Chr17:4825274-4826721 (-)



Homology
more
  • Human Ortholog
    TTLL2, tubulin tyrosine ligase like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTLL2, tubulin tyrosine ligase like 2
  • Synonyms
    C6orf104, dJ366N23.3, NYD-TSPG
  • Links
    NCBI Gene ID: 83887
    neXtProt AC: NX_Q9BWV7
    UniProt: Q9BWV7

  • Chr Location
    6q27; chr6:167325071-167359503 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    348 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079722 Ensembl Gene Model | MGI Sequence Detail 1812 C57BL/6J ±  kb
transcript ENSMUST00000115747 Ensembl | MGI Sequence Detail 1642 Not Applicable  
polypeptide ENSMUSP00000111413 Ensembl | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1
Other
Accession IDs
less
MGI:3779421
References
more
  • Summaries
    All 363
    Developmental Gene Expression 1
    Diseases 6
    Gene Ontology 4
    Phenotypes 348
  • Earliest
    J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
  • Latest
    J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory