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Cttnbp2 Gene Detail
Summary
  • Symbol
    Cttnbp2
  • Name
    cortactin binding protein 2
  • Synonyms
    3010022N24Rik, 4732477G22Rik, 9130022E09Rik, Cortbp2, ORF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353467
    NCBI Gene: 30785
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:18366477-18514842 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 8.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4745 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353467
 protein coding gene Chr6:18366470-18515216 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030476
 protein coding gene Chr6:15664555-15830319 (-)
A/J MGP_AJ_G0030449
 protein coding gene Chr6:15020411-15170230 (-)
AKR/J MGP_AKRJ_G0030376
 protein coding gene Chr6:15544019-15700999 (-)
BALB/cJ MGP_BALBcJ_G0030458
 protein coding gene Chr6:15106884-15258293 (-)
C3H/HeJ MGP_C3HHeJ_G0030172
 protein coding gene Chr6:15414426-15566868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030913
 protein coding gene Chr6:16162717-16327563 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028124
 protein coding gene Chr6:13945561-14093021 (-)
CAST/EiJ MGP_CASTEiJ_G0029574
 protein coding gene Chr6:15330888-15492902 (-)
CBA/J MGP_CBAJ_G0030150
 protein coding gene Chr6:16690954-16862413 (-)
DBA/2J MGP_DBA2J_G0030294
 protein coding gene Chr6:14938964-15091837 (-)
FVB/NJ MGP_FVBNJ_G0030248
 protein coding gene Chr6:14781850-14928877 (-)
LP/J MGP_LPJ_G0030381
 protein coding gene Chr6:15755459-15912469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030284
 protein coding gene Chr6:17850344-18027254 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030943
 protein coding gene Chr6:15427920-15601973 (-)
PWK/PhJ MGP_PWKPhJ_G0029288
 protein coding gene Chr6:14616180-14765666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029124
 protein coding gene Chr6:15320610-15474223 (-)
WSB/EiJ MGP_WSBEiJ_G0029650
 protein coding gene Chr6:15362319-15519464 (-)



Homology
more
  • Human Ortholog
    CTTNBP2, cortactin binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTTNBP2, cortactin binding protein 2
  • Synonyms
    C7orf8, CORTBP2, Orf4
  • Links
    NCBI Gene ID: 83992
    neXtProt AC: NX_Q8WZ74
    UniProt: Q8WZ74

  • Chr Location
    7q31.31; chr7:117710651-117874139 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    17
  • cDNA Data
    33
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000416 Ensembl Gene Model | MGI Sequence Detail 148366 C57BL/6J ±  kb
    transcript ENSMUST00000090601 Ensembl | MGI Sequence Detail 5183 Not Applicable  
    polypeptide ENSMUSP00000088089 Ensembl | MGI Sequence Detail 1648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006037 cortactin-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR050719 Cortactin-binding and Actin Dynamics Regulator
      IPR019131 Cortactin-binding protein-2, N-terminal
      IPR050889 Dendritic Spine Regulation and Scaffold
    • GlyGen
      B9EJA2 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 36
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915319, MGI:1921814, MGI:2141584, MGI:3036231
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:60184 Ellsworth RE, et al., Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1172-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory