Mn1 MGI Mouse Gene Detail - MGI:1261813

Symbol

Mn1
Name

meningioma 1

Feature Type

protein coding gene
IDs

MGI:1261813
NCBI Gene: 433938
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:111565228-111604899 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.86 cM
Mapping Data

2 experiments

SNPs within 2kb

946 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261813	protein coding gene	Chr5:111565145-111604899 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029898	protein coding gene	Chr5:113914847-113957754 (+)
A/J	MGP_AJ_G0029864	protein coding gene	Chr5:109504342-109544189 (+)
AKR/J	MGP_AKRJ_G0029802	protein coding gene	Chr5:112981287-113020828 (+)
BALB/cJ	MGP_BALBcJ_G0029875	protein coding gene	Chr5:110876052-110917114 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0030328	protein coding gene	Chr5:118391570-118434052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027557	protein coding gene	Chr5:104347198-104386815 (+)
CAST/EiJ	MGP_CASTEiJ_G0029003	protein coding gene	Chr5:112293550-112338996 (+)
CBA/J	MGP_CBAJ_G0029562	protein coding gene	Chr5:122813959-122859585 (+)
DBA/2J	MGP_DBA2J_G0029712	protein coding gene	Chr5:109582067-109621937 (+)
FVB/NJ	MGP_FVBNJ_G0029669	protein coding gene	Chr5:108270186-108313905 (+)
LP/J	MGP_LPJ_G0029800	protein coding gene	Chr5:114495295-114538245 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029700	protein coding gene	Chr5:127441307-127485156 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030369	protein coding gene	Chr5:112412430-112452861 (+)
PWK/PhJ	MGP_PWKPhJ_G0028717	protein coding gene	Chr5:108165721-108205950 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028555	protein coding gene	Chr5:109885584-109925016 (+)
WSB/EiJ	MGP_WSBEiJ_G0029079	protein coding gene	Chr5:112908592-112950677 (+)

Human Ortholog

MN1, MN1 proto-oncogene, transcriptional regulator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MN1, MN1 proto-oncogene, transcriptional regulator
Synonyms

CEBALID, dJ353E16.2, MGCR, MGCR1, MGCR1-PEN
Links

HGNC:7180

NCBI Gene ID: 4330

neXtProt AC: NX_Q10571

UniProt: Q10571
Chr Location

22q12.1; chr22:27748277-27801756 (-) GRCh38

MGI Vertebrate Homology

Mn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MN1
Gene Tree

Mn1

Diseases

3 with human MN1 associations

				Human Disease	Mouse Models
				familial meningioma IDs familial meningioma DOID:4586 MESH:C537443 NCI:C5301 UMLS_CUI:C1333989
				meningioma IDs meningioma DOID:3565 DOID:1137 DOID:3554 DOID:3567 DOID:4750 ICD10CM:D32.9 MESH:D008579 NCI:C3230 NCI:C6971 UMLS_CUI:C0025286 UMLS_CUI:C1334698
				myeloid leukemia IDs myeloid leukemia DOID:8692 DOID:8878 DOID:8879 DOID:8910 DOID:9066 DOID:9126 ICD10CM:C92 ICD9CM:205 ICD9CM:205.9 MESH:D007951 NCI:C3172 UMLS_CUI:C0023470

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mn1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die shortly after birth due to cleft palate. Development of several bones in the skull was abnormal with completely absent alisphenoid, squamosal, and vomer bones, hypoplastic basisphenoid, pterygoid, and presphenoid bones, and thinfrontal, parietal, and interparietal bones.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

23
cDNA Data

46
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mn1

ZFIN mn1b

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS39214.1

Ensembl

ENSMUSG00000070576 (Evidence)
NCBI Gene

433938

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070576	Ensembl Gene Model \| MGI Sequence Detail	39672	C57BL/6J	± kb
transcript	ENSMUST00000094463	Ensembl \| MGI Sequence Detail	6860	Not Applicable
polypeptide	ENSMUSP00000092034	Ensembl \| MGI Sequence Detail	1297	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029632 transcriptional activator MN1

(term hierarchy)
InterPro Domains

IPR037644 Transcriptional activator MN1

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All nucleic 47

cDNA 46

Primer pair 1

Microarray probesets 2

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MGI:3034798, MGI:3505791

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:324231 Lehman NL, et al., Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes. Nat Commun. 2022 Apr 19;13(1):2083

TSS for Mn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47933	Chr5:111564475-111564485 (+)	-748 bp
Tssr47934	Chr5:111565129-111565172 (+)	-77 bp
Tssr47935	Chr5:111565183-111565185 (+)	-44 bp
Tssr47936	Chr5:111565625-111565636 (+)	403 bp
Tssr47937	Chr5:111566052-111566069 (+)	833 bp
Tssr47938	Chr5:111566087-111566099 (+)	865 bp
Tssr47939	Chr5:111566119-111566134 (+)	899 bp
Tssr47940	Chr5:111566517-111566528 (+)	1,295 bp
Tssr47941	Chr5:111566574-111566581 (+)	1,350 bp
Tssr47942	Chr5:111566880-111566927 (+)	1,676 bp
Tssr47943	Chr5:111568026-111568054 (+)	2,812 bp
Tssr47944	Chr5:111568115-111568126 (+)	2,893 bp
Tssr47945	Chr5:111577083-111577133 (+)	11,880 bp
Tssr47946	Chr5:111602780-111602784 (+)	37,554 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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