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Wdr72 Gene Detail
Summary
  • Symbol
    Wdr72
  • Name
    WD repeat domain 72
  • Feature Type
    protein coding gene
  • IDs
    MGI:3583957
    NCBI Gene: 546144
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:74017608-74190485 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 41.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4556 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3583957
 protein coding gene Chr9:74017608-74190590 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035030
 protein coding gene Chr9:74360090-74534039 (+)
A/J MGP_AJ_G0035011
 protein coding gene Chr9:71764311-71939194 (+)
AKR/J MGP_AKRJ_G0034940
 protein coding gene Chr9:73481656-73660590 (+)
BALB/cJ MGP_BALBcJ_G0035003
 protein coding gene Chr9:71447746-71621194 (+)
C3H/HeJ MGP_C3HHeJ_G0034712
 protein coding gene Chr9:73957298-74134568 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035522
 protein coding gene Chr9:76319136-76499097 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032433
 protein coding gene Chr9:71161301-71330425 (+)
CAST/EiJ MGP_CASTEiJ_G0034034
 protein coding gene Chr9:74284998-74473282 (+)
CBA/J MGP_CBAJ_G0034685
 protein coding gene Chr9:78947556-79133226 (+)
DBA/2J MGP_DBA2J_G0034844
 protein coding gene Chr9:71443664-71618825 (+)
FVB/NJ MGP_FVBNJ_G0034786
 protein coding gene Chr9:70770259-70940792 (+)
LP/J MGP_LPJ_G0034925
 protein coding gene Chr9:74614146-74794531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034827
 protein coding gene Chr9:80088168-80278738 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035544
 protein coding gene Chr9:73645137-73826787 (+)
PWK/PhJ MGP_PWKPhJ_G0033738
 protein coding gene Chr9:71729666-71905720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033571
 protein coding gene Chr9:73888758-74068669 (+)
WSB/EiJ MGP_WSBEiJ_G0034146
 protein coding gene Chr9:73558698-73740629 (+)



Homology
more
  • Human Ortholog
    WDR72, WD repeat domain 72
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR72, WD repeat domain 72
  • Synonyms
    AI2A3
  • Links
    NCBI Gene ID: 256764
    neXtProt AC: NX_Q3MJ13
    UniProt: Q3MJ13

  • Chr Location
    15q21.3; chr15:53513741-53762878 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wdr72 mouse models; 1 with human WDR72 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display hypomineralized enamel, ameloblast abnormalities and decreased post-weaning body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 546144 NCBI Gene Model | MGI Sequence Detail 172878 C57BL/6J ±  kb
    transcript NM_001033500 RefSeq | MGI Sequence Detail 5226 C57BL/6  
    polypeptide D3YYM4 UniProt | EBI | MGI Sequence Detail 1114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143335
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory